Monday September 24, 2012 15:00 - 15:30 @ Rhodes 6

Human genetic variation: from population sequencing to cellular function

Abstract:

The dramatic decrease in DNA sequencing costs in the last few years has allowed direct full genome sequence studies of genetic diversity by sequencing multiple individuals.  As well supporting evolutionary and population genetic studies, this also allows phenotype association studies to be extended to all types of genetic variation, not just common variation assayed using genotyping chips.   I will discuss some of the recent results we have been involved in from the 1000 Genomes Project, and various studies to correlate genetic variation with variation between individuals in cellular traits such as microRNA expression, and protein binding to DNA measured by ChIP-seq.