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Saturday, September 22
 

9:00am

Career Session A1 - Presentation skills: how to capture your audience

Saturday, 22 September, 9:00-17:30 (lunch 12:00-14:30) @ Gallieni 4 


The goal of this workshop is to develop an ability to create and deliver successful presentations with confidence.

 

In this hands on, practice driven workshop, a two-trainer team, a scientist/free-lance trainer and a theater director, will teach you the essential elements of scientific presentations. You will learn how to design clear and effective scientific presentations and how to use your voice and body language to capture your audience and enhance your confidence.

 

Please prepare a 2-minute poster presentation to use as practice material during the workshop.

 

Cost for this workshop: €40

Register now to attend this workshop

 


Trainers
AD

Alfons Duczek

Free-lance theatre educator
Saturday, 22 September, 9:00 - 17:30 (lunch 12:00-14:30) @ Gallieni 4 
JC

Jon Copley

Lecturer in Marine Ecology & free-lance science writer & trainer with SciConnect, University of Southampton | SciConnect
Saturday, 22 September, 9:00 - 17:30 (lunch 12:00-14:30) @ Gallieni 4 


Saturday September 22, 2012 9:00am - 5:30pm
Gallieni 4

9:00am

Career Session A2 - Job application: Understand the do's and don'ts

Saturday, 22 September, 9:00-17:30 (lunch 12:00-14:30) @ Gallieni 2 


As you look for a suitable job you must stand out from the crowd of other well-qualified job-seekers to attract the attention of potential employers. During this six-hour workshop you will learn how to:

  • identify and present the specific skills you have acquired during 
    your thesis and/or post doc;
  • you will hear about the importance of tailoring your application to 
    different types of jobs;
  • how to write an attractive CV and engaging cover letter;
  • how to prepare for and present yourself convincingly in an interview;
  • and how networking can help you find out about potential careers, 
    as well as available jobs.

 

Although focusing on non-academic career paths, much of the advice will be relevant to those applying to academic positions.

 

In the morning of this full-day workshop we will prepare for the Career Options Lunch. Please also register to this lunch workshop, to ensure you get optimal use from the training.

 

You will be asked to send your CV one month before the conference so that we can tailor the workshop to your needs.

 

Cost for this workshop: €40

Register now to attend this workshop

 


Trainers
BJ

Barbara Janssens

Saturday, 22 September, 9:00 - 17:30 (lunch 12:00-14:30) @ Gallieni 2 


Saturday September 22, 2012 9:00am - 5:30pm
Gallieni 2

10:00am

ADP-ribosyation in signaling events

Participants need to register for The EMBO Meeting 2012 to attend this special interest symposium.

 

Understanding protein modifications can provide powerful tools to study basic biology, and open new avenues for disease treatment. Recent years have seen a tremendous rise in both interest in, and understanding of, the players, mechanisms, and consequences of ADP-ribosylation. A fair understanding of this process is deemed important not the least for the development of safe therapeutics for treatment of cancer. Here, European researchers will present their recent data on the writers, readers, and erasers of ADP-ribosylation.

 

To view the full programme, please click here.


Exhibitors
IA

Ivan Ahel

Saturday September 22, 2012 15:10 - 15:40 @ Rhodes 7 Structure and catalytic mechanism of PARG
FD

Françoise Dantzer

Saturday September 22, 2012 10:30 - 11:00 @ Rhodes 7   Novel functions of PARPs in heterochromatin dynamics: molecular and cellular aspects
MD

Mariella di Girolamo

Saturday September 22, 2012 13:00 - 13:30 @ Rhodes 7 ADP-ribosylated proteins as old and new drug targets for anticancer therapy
MH

Martin Högbom

Saturday September 22, 2012 15:40 - 16:00 @ Rhodes 7 Structure and Mechanism of mono-ADP-ribosylhydrolase DraG
FK

Friedrich Koch-Nolte

Saturday September 22, 2012 11:40 - 12:00 @ Rhodes 7   Blocking mammalian and toxin ARTCs with Nanobodies
LL

Lari Lehtiö

Saturday September 22, 2012 14:30 - 14:50 @ Rhodes 7 Selective Inhibition of Tankyrases  
BL

Bernhard Lüscher

Saturday September 22, 2012 13:30 - 14:00 @ Rhodes 7   Regulation of NF-kB signaling by ARTD10-dependent mono-ADP-ribosylation
AM

Antonio Macchiarulo

Saturday September 22, 2012 11:00 - 11:20 @ Rhodes 7   From Target Specificity to Targeted Polypharmacology of PARP Inhibitors
RS

Raffaella Santoro

Saturday September 22, 2012 10:00 - 10:30 @ Rhodes 7 Non-coding RNA link PARP1 to heterochromatin
HS

Herwig Schüler

Organizer
Saturday September 22, 2012 11:20 - 11:40 @ Rhodes 7 A chemical probe for ARTD3/PARP3
GT

Gyula Timinszky

Saturday September 22, 2012 16:00 - 16:30 @ Rhodes 7   The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks
MZ

Mathias Ziegler

Saturday September 22, 2012 16:30 - 17:00 @ Rhodes 7 ADP-ribose and NAD metabolism in mitochondria


Saturday September 22, 2012 10:00am - 5:15pm
Rhodes 7

12:15pm

Career Session B1 - Career Options lunch

Saturday, 22 September, 12:15-14:15 @ Le Mykonos Restaurant 

 

Scientists who have chosen career paths outside academic research will lead this interactive lunchtime session and talk about their jobs, allowing participants to gain an insight into some of the career options available.  The session is organised as round-table discussion over lunch with speakers highlighting different career paths.

 

Confirmed speakers include:

1. Science Management: Martine Avella, Grant Project Officer, Institute Biology Valrose, Nice

2. Science Policy: Michele Garfinkel, EMBO, Heidelberg

3. Industry 1: Hervé Groux, CEO at Immunosearch, Grasse, Côte d'Azur

4. Industry 2: Philippe Couttet, Lab Head, Novartis, Basel

5. Regulatory Affairs: Annalisa Vezzaro, Regulatory Affairs assistant, ABC Farmaceutici Spa, Ivrea (Turin)

6. Science Education: Sophie Chabanis-Davidson, Science Teacher at European School Karlsruhe

7. Public Affairs: Sarah Blackford, Head of Education and Public Affairs, Society for Experimental Biology, Lancaster (UK)

8. Scientific Publishing: Anke Sparmann, The EMBO Journal, Heidelberg (DE)

9. Scientific Sales/ Marketing: Pierre Lacaze, Sales & Marketing Director, Eurogentec, Liège (BE)

 

Cost for this event: €20

Register now to attend this networking lunch

 


Speakers
MA

Martine Avella

Grant Project Officer, Institute Biology Valrose
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant   Martine Avella is a Project Officer at the Institute of Biology Valrose in Nice. She is in charge of optimizing the creative phase of grant applications in response to calls in order to maximize funding chances. Her work involves setting up, editing and harmonizing convincing and focused projects for submission to public or private agencies. Her mission... Read More →
SB

Sarah Blackford

Head of Education and Public Affairs, Society for Experimental Biology
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant   Sarah Blackford is Head of Education & Public Affairs at the Society for Experimental Biology (SEB), an international learned society based in London. Sarah plays a key role in SEB’s public relations and policy advocacy at the national and wider European level. This involves coordinating consultations, drafting policy documents and representing... Read More →
SC

Sophie Chabanis-Davidson

Science Teacher, European School Karlsruhe
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant    nitially trained as a biochemist, Sophie Chabanis-Davidson spent 10 years as a researcher at EMBL and Heidelberg University after completing a PhD in Paris France. Her long-term interest in teaching and communication of science, was developed further when she taught during her PhD and at EMBL.  The European Learning Laboratory for the Life... Read More →
PC

Philippe Couttet

Lab Head, Novartis
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant   Philippe Couttet is a Research Investigator, heading the Pathway Integration Lab, at the Novartis Institute of Biomedical Research in Basel.  | He studied Biochemistry at the University Pierre et Marie Curie in Paris. During his PhD, Philippe studied the mechanisms of mRNA degradation pathways in mammals (Institut Jacques Monod, CNRS, Paris). Then he... Read More →
avatar for Michele Garfinkel

Michele Garfinkel

EMBO
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant  Monday September 24, 2012 18:30 - 18:35 @ Rhodes 6    Michele Garfinkel is the manager of the Science Policy Programme at the European Molecular Biology Organization. Previously she was a policy analyst at the J. Craig Venter Institute, where she worked on societal issues related to the emerging technologies of genomics, particularly... Read More →
HG

Hervé Groux

CEO, Immunosearch
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant 
PL

Pierre Lacaze

Sales & Marketing Director, Eurogentec
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant    Pierre Lacaze is the Sales & Marketing Director, Research Reagents, Eurogentec (BE). As such he is responsible for a group of 50 people who actively market Genomics and Proteomics products and services worldwide. A plant geneticist by training, he quickly moved into Business Development after his Ph.D. which he undertook at Sanofi. Pierre has... Read More →
avatar for Anke Sparmann

Anke Sparmann

Editor, EMBO
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant  Sunday September 23, 2012 13:15 - 14:15 @ Agora 2    Anke Sparmann is a professional editor at The EMBO Journal, with a background in signal transduction and chromatin & transcription.  During her post-doctoral work, completed before her move to publishing, she focused on analyzing dynamic changes of Polycomb-complex... Read More →
AV

Annalisa Vezzaro

Regulatory Affairs assistant, ABC Farmaceutici Spa
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant    Annalisa Vezzaro is a Regulatory Affairs assistant since 2011 at ABC Farmaceutici, an Italian pharmaceutical company located near Turin. As a Regulatory Affairs assistant, she helps ensuring that the company complies with all the regulations concerning the business of the company (e.g. the launch and the maintenance of a medicinal product in the... Read More →


Saturday September 22, 2012 12:15pm - 2:15am
Le Mykonos Restaurant

1:00pm

Break
Saturday September 22, 2012 1:00pm - 2:30pm
TBA

1:00pm

Break
Saturday September 22, 2012 1:00pm - 2:30pm
TBA

1:00pm

Break
Saturday September 22, 2012 1:00pm - 2:30pm
TBA

2:00pm

EuroGlycoScience Forum

Participants need to register for The EMBO Meeting 2012 to attend this special interest symposium.

 

Protein glycosylation in human disease

The majority of human proteins are posttranslationally modified by the addition of complex oligosaccharides (glycans). Glycans are integral part of glycoproteins and as such significantly participate in structural and functional roles of these proteins in disease mechanisms. Due to structural complexity of glycans and the absence of genetic template for their synthesis, glycan parts of glycoproteins were nearly completely ignored in the past, but recent technological advances enabled analysis of their importance in numerous disease mechanisms. Among other functions, protein glycosylation was shown to be an essential regulator of effector functions of IgG, membrane half-life of various receptors and pharmacodynamic properties of biological therapeutics. Changes in glycosylation were implicated in the progression and/or predisposition of numerous diseases including cancer, diabetes, autoimmune and infectious diseases. Recent population studies of the human glycome indicated very large variability in glycome composition between individuals which derived from both genetic background and environmental influence. Genome wide association studies of the glycome identified proteins that were previously implicated in mechanisms of several major diseases as major regulators of protein glycosylation. Glycosylation changes regulated by these genes were also previously implicated in disease mechanisms (e.g. decreased galactosylation in rheumatoid arthritis), indicating that at least part of disease relevance of these genes derives from their role in protein glycosylation. Human glycome is estimated to be several orders of magnitude more complex than the proteome, thus numerous studies will be needed to reveal the role of glycans in specific molecular processes, but even the current level of knowledge strongly supports their importance in many diseases.

 

To view the full programme, please click here.

 

For further information, please contact the organizers: Sabine Flitsch and Gordan Lauc.


Exhibitors
SH

Stuart Haslam

Imperial College London
Saturday September 22, 2012 14:40 - 15:10 @ Rhodes 6    The glycobiology of infection and immunity Abstract: Glycans, in the form of polysaccharides or glycoconjugates (bound to proteins and lipids), are found on the surface of every cell in nature. Glycans engage with receptors (called lectins or glycan binding proteins) to mediate cell-cell recognition in numerous biological processes including pathogen/host... Read More →
GL

Gordan Lauc

Faculty of Pharmacy and Biochemistry, University of Zagreb
Saturday September 22, 2012 14:00 - 14:40 @ Rhodes 6    The ubiquitous importance of protein glycosylation Abstract: | The majority of all proteins are glycosylated and their glycan parts have numerous structural, functional and regulatory roles. However, due to their structural complexity, the absence of a direct genetic template and technological limitations, the knowledge about glycans is lagging significantly behind the... Read More →
FN

Falk Nimmerjahn

University of Erlangen-Nürnberg
Saturday September 22, 2012 15:10 - 15:40 @ Rhodes 6    Modulation of IgG function by Fc glycosylation Abstract: IgG antibodies are the primary mediators of protective humoral immunity against pathogens and have been used therapeutically for over a century. They were first used as antitoxins for the treatment of infectious diseases in the pre-antibiotic era. Today, hyperimmune sera from human donors recovering from infection... Read More →
PM

Pauline M. Rudd

Glycobiology Group, National Institute for Bioprocessing Research and Training
Saturday September 22, 2012 16:30 - 17:00 @ Rhodes 6    Glycans as biomarkers of disease Pauline M Rudd, Jane Telford, Jennifer C. Byrne, Barbara Adamcyzk, Radka Saldova Abstract: Over half of all proteins are glycosylated, and alterations in glycosylation are common in both physiological and pathological processes. Glycan processing is, in the first instance, determined by genes (1) that code for 600 or so... Read More →
US

Uli Scherer

Department of Rheumatology, Leiden University Medical Center
Saturday September 22, 2012 16:00 - 16:30 @ Rhodes 6   Glycosylation Changes in Autoimmune Diseases Abstract: In many autoimmune diseases, including rheumatoid arthritis (RA), antibodies against self-antigens are believed to be the causative agent that drives disease pathogenesis. Antibodies are glycoproteins, with glycans attached to both constant and variable regions of the molecule. These glycans strongly influence... Read More →


Saturday September 22, 2012 2:00pm - 5:00pm
Rhodes 6

2:30pm

Career Session C1 - Science communication: Make science make sense

Saturday, 22 September, 14:30 - 17:30 Gallieni 7 


How to explain your research to your granny: scientists' parents, grandparents and friends often look puzzled when they are confronted with science and they don't seem to understand the importance of the individual scientist's research. Participants of this session will learn how to communicate their own research effectively to non-scientists.

 

Participants will learn about:

  • What level of information to give
  • How to structure the information to be conveyed
  • What kind of language should be used or avoided
  • How to spark enthusiasm and maintain interest

 

Cost for this workshop: €20

Register now to attend this workshop

 


Trainers
avatar for Samuel Caddick

Samuel Caddick

Editor, EMBO
Saturday, 22 September, 14:30 - 17:30 @ Gallieni 7   Sam joined EMBO reports in April 2007. He currently handles scientific content for the Upfront section, as well as Science & Society content. He also coordinates the journal. Sam was awarded his PhD in plant molecular biology by the University of East Anglia in Norwich, UK, in 2005. He continued his research into inositol phosphate kinases and pathways of... Read More →


Saturday September 22, 2012 2:30pm - 5:30pm
Gallieni 7

2:30pm

Career Session C2 - How to get your paper published

Saturday, 22 September, 14:30-17:30 @ Gallieni 5 

 

Senior scientific editors from EMBO will provide hands on advice on how to increase your chances to publish a high level research paper.



The published scientific paper remains the key marker for the success and quality of a project or a researcher. Impact and journal name are widely used in hiring and funding assessments. The pressures for scientists to publish in a few select journals is therefore increasing in an expanding and increasingly crowded research landscape.

 

Cost for this workshop: €20

Register now to attend this workshop

 


Speakers
avatar for Thomas Lemberger

Thomas Lemberger

Chief Editor Molecular Systems Biology and Deputy Head of Scientific Publications, EMBO
Saturday September 22, 2012 14:30 - 17:30 @ Gallieni 5  Sunday September 23, 2012 13:15 - 14:15 @ Agora 2  Monday September 24, 2012 18:50 - 19:05 @ Rhodes 6    Integrating 'Source Data' Into Scientific Papers Abstract: The effective and unrestricted exchange of peer-reviewed research data is essential to the advancement of science. This requires making published data available, searchable and re-usable... Read More →
avatar for Bernd Pulverer

Bernd Pulverer

Chief Editor The EMBO Journal and Head of Scientific Publications, EMBO
Saturday September 22, 2012 14:30 - 17:30 @ Gallieni 5  Sunday September 23, 2012 13:15 - 14:15 @ Agora 2  Monday September 24, 2012 18:35 - 18:50 @ Rhodes 6    Transparent Peer Review Abstract: The peer reviewed research paper remains the main conduit for the exchange of research discoveries. With the growth and diversification of global research, publishing in selected journals and citation... Read More →


Saturday September 22, 2012 2:30pm - 5:30pm
Gallieni 5

4:30pm

Break
Saturday September 22, 2012 4:30pm - 6:00pm
TBA

5:30pm

Welcome Address
Conference chair
avatar for Jacques Pouysségur

Jacques Pouysségur

Institute de Biologie du Développement et Cancer

Saturday September 22, 2012 5:30pm - 5:45pm
Auditorium

5:45pm

Controlling the cell cycle - Paul Nurse

Keynote Lecture

Abstract:

Both S-phase and mitosis are common to all cell cycles and both are necessary for the two newly divided cells to receive a full complement of genes.  In fission yeast the onset of S-phase and mitosis can be controlled by a single cyclin dependent kinase (CDK) with different levels of CDK activity bringing about progression through the cell cycle in an orderly fashion.  A low CDK activity is sufficient to bring about S-phase whilst a high activity blocks a further S-phase and is needed for onset of mitosis.  A G2 cell can be programmed to undergo either S-phase or mitosis simply by modifying CDK activity indicating there is no inherent direction in the cell cycle.  Activation of CDK activity is determined by growth rate and cell size, with cell size determined in part by a gradient mechanism.  A genomic wide screen for small sized mutants has identified new genes that act in previously unidentified pathways to regulate CDK activity at mitotic onset.


Speakers
avatar for Maria Leptin

Maria Leptin

EMBO Director, EMBO
avatar for Paul Nurse

Paul Nurse

Saturday September 22, 2012 17:45 - 18:30 @ Auditorium 


Saturday September 22, 2012 5:45pm - 6:30pm
Auditorium

6:30pm

Chromatin & chromosomes – The dynamic genome
Speakers
avatar for Adrian Bird

Adrian Bird

Wellcome Trust Centre for Cell Biology, University of Edinburgh
Saturday September 22, 2012 19:30 - 20:00 @ Auditorium    The Dinucleotide CG as a Genomic Signalling Module Abstract:  The DNA sequence 5'CG (CpG) is unusual in several respects. It is self-complementary and can exist in three chemical forms depending on the modification status of its cytosine moiety. To understand the functional significance of the CpG dinucleotide, we study proteins that bind either its methylated or... Read More →
avatar for Ingrid Grummt

Ingrid Grummt

German Cancer Research Centre
Saturday September 22, 2012 19:00 - 19:30 @ Auditorium    Non-coding RNA controls epigenetic processes Abstract: Constitutive heterochromatin exerts a crucial function in maintaining genomic stability. I will talk about the molecular mechanisms that direct epigenetic silencing of rRNA genes, focussing on the role of the chromatin remodeling complex NoRC in targeting chromatin modifying enzymes to the rDNA promoter... Read More →
avatar for Steven Henikoff

Steven Henikoff

HHMI & Fred Hutchinson Cancer Research Centre
Saturday September 22, 2012 18:30 - 19:00 @ Auditorium    Mapping genome-wide nucleosome dynamics Abstract: Eukaryotic gene expression occurs in the context of chromatin, and maintaining a region accessible to DNA-binding proteins for transcriptional regulation requires active processes that mobilize nucleosomes. Our approach to studying these processes has been to map nucleosome dynamics genome-wide, and we have... Read More →

Conference chair
avatar for Julie Ahringer

Julie Ahringer

Wellcome Trust/Cancer Research UK Gurdon Institute

Saturday September 22, 2012 6:30pm - 8:00pm
Auditorium
 
Sunday, September 23
 

9:00am

RNA life – from birth to death
Speakers
avatar for Elisa Izaurralde

Elisa Izaurralde

Department of Biochemistry, Max Planck Institute for Developmental Biology
Sunday September 23, 2012 9:30 - 10:00 @ Auditorium    Regulation of mRNA expression by miRNAs and RNA-binding proteins Abstract: The focus of our research is the elucidation of the molecular mechanisms that regulate gene expression at the post-transcriptional level. In particular, we study three specific aspects of this regulation: the mechanisms of miRNA-mediated gene silencing, mRNA quality control and degradation, as well... Read More →
avatar for Robert H. Singer

Robert H. Singer

Albert Einstein College of Medicine, Yeshiva University
Sunday September 23, 2012 10:00 - 10:30 @ Auditorium   Following Single mRNAs from Birth to Death in Living Cells Abstract: Live cell imaging has been instrumental in analyzing the dynamic properties of RNA. New technologies in optical microscopy and fluorescent probe development have been pushing the envelope of our analysis capabilities. We have been dedicated to developing and implementing these technologies to... Read More →
avatar for David Tollervey

David Tollervey

Wellcome Trust Centre for Cell Biology, University of Edinburgh
Sunday September 23, 2012 9:00 - 9:30 @ Auditorium    Lighting up RNA interactions in living cells Abstract: In vivo analyses of RNA processing are impeded by two major problems: 1) The kinetics of the process must generally be inferred from steady-state levels of intermediates, so rapid processing events are essentially invisible, particularly if they occur cotranscriptionally. 2) The structures of RNA-protein... Read More →

Conference chair
avatar for Elena Conti

Elena Conti

Max Planck Institute of Biochemistry

Sunday September 23, 2012 9:00am - 10:30am
Auditorium

10:30am

Break
Sunday September 23, 2012 10:30am - 11:00am
TBA

11:00am

Cell Competition
Speakers
SC

Sergio Casas-Tintó

Cajal Institute
Sunday September 23, 2012 11:30 - 11:45 @ Rhodes 6    Troponin I loss yields to cell polarity loss, cell cycle arrest and cell competition Abstract: Troponin I (TnI) is an actin binding protein involved in muscle contraction but has a novel non-muscular function recently documented. The underlying mechanisms and relevance of this new role of TnI are under study. TnI is expressed in the preblastodermic embryo, prior to muscle... Read More →
YF

Yasuyuki Fujita

Hokkaido University, Institute for Genetic Medicine
Sunday September 23, 2012 12:15 - 12:30 @ Rhodes 6    Interaction between normal and transformed epithelial cells in mammals Abstract: At the initial step of carcinogenesis, transformation occurs in a single cell within an epithelial sheet, and the transformed cells grow while being surrounded by normal epithelial cells. However, it was not clear what happens at the boundary between normal and transformed cells in mammals... Read More →
LJ

Laura Johnston

Columbia University Medical Center
Sunday September 23, 2012 11:00 - 11:30 @ Rhodes 6    Homeostatic Roles of Myc in organ growth: lessons from Drosophila Abstract: Metazoan tissues are complex assemblies of cell populations in which cells can differ in their ability to proliferate.  In growing epithelia such as the developing Drosophila wing, cells communicate information about their growth and metabolism in a process called cell competition, a homeostatic... Read More →
avatar for Eduardo Moreno

Eduardo Moreno

Institute of Cell Biology, University of Bern
Sunday September 23, 2012 12:30 - 13:00 @ Rhodes 6   Cellular fitness from Drosophila to mammals Abstract: I will describe the molecules and mechanisms through which animal cells reveal their fitness to the neighboring cells within tissues. The conserved roles of the "Flower Code" and Sparc in Drosophila and mammals will be discussed. Finally I will highlight the connections between the molecular determinants that reveal and... Read More →
JV

Jean-Paul Vincent

Division of Developmental Neurobiology
Sunday September 23, 2012 11:45 - 12:15 @ Rhodes 6   Death, survival and Wingless signalling in developing wing imaginal discs of Drosophila Abstract: Epithelia have evolved several quality control mechanisms that lead to the elimination of defective or mis-specified cells. The widespread apoptosis that occurs following epithelial disruption provides an extreme example. I will describes our studies aimed at delineating the... Read More →


Sunday September 23, 2012 11:00am - 1:00pm
Rhodes 6

11:00am

Cell migration
Speakers
CG

Cedric Gaggioli

IRCAN
Sunday September 23, 2012 12:15 - 12:30 @ Rhodes 7    JAK/STAT signaling controls stromal fibroblast activation and mediates onset of invasive tumor microenvironment in epithelial cancer Abstract: Tumor-stroma signaling crosstalk contributes to tumor ecosystem modifications and cancer cell spreading. Carcinoma associated fibroblasts (CAF) display enhanced extracellular matrix remodeling capacities, which enables carcinoma... Read More →
ER

Erez Raz

Institute of Cell Biology, ZMBE
Sunday September 23, 2012 11:00 - 11:30 @ Rhodes 7    Motility and guided migration of zebrafish Primordial Germ Cells Abstract: The migration of Primordial Germ Cells in zebrafish serves as a model for single-cell migration in development, homeostasis, and disease. We use this model to investigate the basic cellular mechanisms directing cells into motile behavior and those allowing the cells to respond to directional cues. We... Read More →
PR

Pernille Rørth

Institute of Molecular and Cell Biology
Sunday September 23, 2012 11:45 - 12:15 @ Rhodes 7    Collective cell migration and directionality Abstract: Collective cell migration has become appreciated as a major mode of cell migration in vivo, notably in tissue vascularization, wound healing and many cases of developmental morphogenesis, as well as during invasion and dissemination of tumors, specifically carcinomas. While some features of collective migration are... Read More →
ES

Erik Sahai

Tumour Cell Biology Laboratory
Sunday September 23, 2012 12:30 - 13:00 @ Rhodes 7    Imaging changes in signaling and differentiation during the metastatic process Abstract: Until recently most studies of metastasis only measured the end-point of the process - macroscopic metastases. While these studies have provided much useful information, the details of the metastatic process have remained somewhat mysterious due to difficulties in... Read More →
AS

Akira Sakakibara

Nagoya University Graduate School of Medicine
Sunday September 23, 2012 11:30 - 11:45 @ Rhodes 7   Microtubule dynamics in neocortical neurons during distinct modes of migration and polarization in the developing mouse cerebrum Abstract: Neuronal migration and process formation require microtubule (MT) function. To understand how MTs are involved in neuronal migration and process formation, we monitored dynamic movements of fluorescently-labeled centrosomes and MT plus ends... Read More →


Sunday September 23, 2012 11:00am - 1:00pm
Rhodes 7

11:00am

Chromatin regulation
Speakers
ED

Elisa Dultz

University of California
Sunday September 23, 2012 12:15 - 12:30 @ Auditorium    Global chromatin reorganization in response to changes in gene expression programs Abstract: The organization of the genome is non-random and important for correct genome function. Specifically, the nuclear envelope was shown to play a critical role in gene regulation. Interactions between genes and the periphery were predominantly found to correlate with repression... Read More →
PF

Peter Fraser

Laboratory of Chromatin & Gene Expression
Sunday September 23, 2012 12:30 - 13:00 @ Auditorium   Nuclear genome organization and gene expression: from cell populations to single molecule analysis of chromosome folding Abstract: The spatial organization of chromatin and chromosomes in the nucleus has been tightly linked to control of genome functions such as transcription, silencing, replication and repair. Analytical techniques to study higher-order chromatin and chromosome... Read More →
FG

Fabien Guidez

King's College London | Institut Universitaire d'Hématologie
Sunday September 23, 2012 11:30 - 11:45 @ Auditorium    Retrotransposition safeguarding in adult tissues by the promyelocytic leukemia zinc finger protein: Dual inhibition of line 1 expression by epigenetic and RNA translation mechanisms Abstract: Stem cell maintenance involves regulation of specific cell program through specific DNA methylation patterning while safeguarding genome integrity of the progenitor pools. PLZF, a... Read More →
MK

Mitzi Kuroda

Harvard Medical School, Department of Genetics
Sunday September 23, 2012 11:00 - 11:30 @ Auditorium    ChIP-mass spectrometry captures protein interactions and modified histones associated with chromatin regulatory complexes in Drosophila Abstract: omprehensive analyses of chromatin-bound regulatory complexes present unique challenges, as removing proteins from the DNA can result in the loss of weak or transient interactions with key partners in function.  To... Read More →
DS

Dirk Schübeler

Friedrich Miescher Institute
Sunday September 23, 2012 11:45 - 12:15 @ Auditorium    DNA sequence determinants of gene repression Abstract: Chromatin and DNA modifications have emerged as a critical component for gene regulation in higher eukaryotes yet how these epigenetic variables are targeted to specific sites of the genome is still poorly understood. We have generated global maps of DNA methylation, histone modifications and replication in higher... Read More →


Sunday September 23, 2012 11:00am - 1:00pm
Auditorium

11:00am

Membrane trafficking
Speakers
JB

John Briggs

EMBL, Structural and Computational Biology
Sunday September 23, 2012 12:30 - 13:00 @ Rhodes 8    The structure and assembly of coated vesicles Abstract: Transport between compartments of eukaryotic cells is mediated by coated vesicles. The archetypal protein coats COPI, COPII and clathrin are conserved from yeast to human. We are applying cryo-electron tomography and correlative light and electron microscopy to study the structure and assembly of coated... Read More →
MG

Malgorzata Garstka

Netherlands Cancer Institute
Sunday September 23, 2012 11:30 - 11:45 @ Rhodes 8    Tollip controls transport of MHC class II molecules Abstract: Major histocompatibility complex (MHC) class II molecules present exogenous antigens to CD4+ T cells that modulate immune responses. MHC class II compartment (MIIC) constitutes a key hub for MHC II antigen presentation, wherein the endocytic, exocytic and degradation pathways intersect. Malfunctions along... Read More →
HR

Howard Riezman

University of Geneva - Sciences II
Sunday September 23, 2012 11:45 - 12:15 @ Rhodes 8    Systematic lipidomic analysis of yeast mutants reveals novel regulation of lipid homeostasis and plasma membrane/ER communication Abstract: We have performed an unbiased, systematic, lipidomics analysis of two collections of yeast mutants ; in the early secretory pathway previously used for an epistatic miniarray profiling (Schuldiner et al, 2005) and a collection of yeast... Read More →
MS

Margaret S. Robinson

University of Cambridge - CIMR
Sunday September 23, 2012 11:00 - 11:30 @ Rhodes 8    Clathrin-mediated trafficking analysed by proteomics and genomics Abstract: Clathrin-coated vesicles (CCVs) transport cargo proteins from one membrane compartment of the cell to another. We have used two approaches to investigate clathrin-mediated trafficking: proteomics and genomics. For the proteomics studies, we made use of our “knocksideways” system to... Read More →
AW

Ann Wehman

Skirball Institute, NYU School of Medicine
Sunday September 23, 2012 12:15 - 12:30 @ Rhodes 8    The lipid flippase TAT-5 inhibits the budding of extracellular vesicles from the surface of C. elegans embryos Abstract: Cells release extracellular vesicles (ECVs) that can influence differentiation, modulate the immune response, promote coagulation, and induce metastasis. Many ECVs form by budding outwards from the plasma membrane, but the molecules that regulate budding... Read More →


Sunday September 23, 2012 11:00am - 1:00pm
Rhodes 8

1:00pm

Break
Sunday September 23, 2012 1:00pm - 2:30pm
TBA

1:15pm

Meet the EMBO Editors

Sunday September 23, 2012 13:15 - 14:15 Agora 2 

 

The editorial teams of the four EMBO scientific publications – The EMBO JournalEMBO reports,Molecular Systems Biology and EMBO Molecular Medicine – warmly invite you for informal discussions over lunch.

We look forward to meeting you, hearing about your research, discussing your views on science and publishing and informing you about the scope and editorial procedures of our journals.

There is no need to register for this event; please feel free to stop by and meet the editors.


Speakers
avatar for Thomas Lemberger

Thomas Lemberger

Chief Editor Molecular Systems Biology and Deputy Head of Scientific Publications, EMBO
Saturday September 22, 2012 14:30 - 17:30 @ Gallieni 5  Sunday September 23, 2012 13:15 - 14:15 @ Agora 2  Monday September 24, 2012 18:50 - 19:05 @ Rhodes 6    Integrating 'Source Data' Into Scientific Papers Abstract: The effective and unrestricted exchange of peer-reviewed research data is essential to the advancement of science. This requires making published data available, searchable and re-usable... Read More →
avatar for Bernd Pulverer

Bernd Pulverer

Chief Editor The EMBO Journal and Head of Scientific Publications, EMBO
Saturday September 22, 2012 14:30 - 17:30 @ Gallieni 5  Sunday September 23, 2012 13:15 - 14:15 @ Agora 2  Monday September 24, 2012 18:35 - 18:50 @ Rhodes 6    Transparent Peer Review Abstract: The peer reviewed research paper remains the main conduit for the exchange of research discoveries. With the growth and diversification of global research, publishing in selected journals and citation... Read More →
avatar for Anke Sparmann

Anke Sparmann

Editor, EMBO
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant  Sunday September 23, 2012 13:15 - 14:15 @ Agora 2    Anke Sparmann is a professional editor at The EMBO Journal, with a background in signal transduction and chromatin & transcription.  During her post-doctoral work, completed before her move to publishing, she focused on analyzing dynamic changes of Polycomb-complex... Read More →


Sunday September 23, 2012 1:15pm - 2:15pm
Agora 2

1:15pm

Meet the Speakers Lunch

Sunday September 23, 2012 13:15 - 14:15Agora 2 

 

Meet the keynote and plenary speakers. This is an ideal opportunity, especially for students and younger scientists, to meet the speaker faculty and ask questions.


Speakers
avatar for Adrian Bird

Adrian Bird

Wellcome Trust Centre for Cell Biology, University of Edinburgh
Saturday September 22, 2012 19:30 - 20:00 @ Auditorium    The Dinucleotide CG as a Genomic Signalling Module Abstract:  The DNA sequence 5'CG (CpG) is unusual in several respects. It is self-complementary and can exist in three chemical forms depending on the modification status of its cytosine moiety. To understand the functional significance of the CpG dinucleotide, we study proteins that bind either its methylated or... Read More →
avatar for Ingrid Grummt

Ingrid Grummt

German Cancer Research Centre
Saturday September 22, 2012 19:00 - 19:30 @ Auditorium    Non-coding RNA controls epigenetic processes Abstract: Constitutive heterochromatin exerts a crucial function in maintaining genomic stability. I will talk about the molecular mechanisms that direct epigenetic silencing of rRNA genes, focussing on the role of the chromatin remodeling complex NoRC in targeting chromatin modifying enzymes to the rDNA promoter... Read More →
avatar for Steven Henikoff

Steven Henikoff

HHMI & Fred Hutchinson Cancer Research Centre
Saturday September 22, 2012 18:30 - 19:00 @ Auditorium    Mapping genome-wide nucleosome dynamics Abstract: Eukaryotic gene expression occurs in the context of chromatin, and maintaining a region accessible to DNA-binding proteins for transcriptional regulation requires active processes that mobilize nucleosomes. Our approach to studying these processes has been to map nucleosome dynamics genome-wide, and we have... Read More →
avatar for Elisa Izaurralde

Elisa Izaurralde

Department of Biochemistry, Max Planck Institute for Developmental Biology
Sunday September 23, 2012 9:30 - 10:00 @ Auditorium    Regulation of mRNA expression by miRNAs and RNA-binding proteins Abstract: The focus of our research is the elucidation of the molecular mechanisms that regulate gene expression at the post-transcriptional level. In particular, we study three specific aspects of this regulation: the mechanisms of miRNA-mediated gene silencing, mRNA quality control and degradation, as well... Read More →
avatar for Robert H. Singer

Robert H. Singer

Albert Einstein College of Medicine, Yeshiva University
Sunday September 23, 2012 10:00 - 10:30 @ Auditorium   Following Single mRNAs from Birth to Death in Living Cells Abstract: Live cell imaging has been instrumental in analyzing the dynamic properties of RNA. New technologies in optical microscopy and fluorescent probe development have been pushing the envelope of our analysis capabilities. We have been dedicated to developing and implementing these technologies to... Read More →
avatar for David Tollervey

David Tollervey

Wellcome Trust Centre for Cell Biology, University of Edinburgh
Sunday September 23, 2012 9:00 - 9:30 @ Auditorium    Lighting up RNA interactions in living cells Abstract: In vivo analyses of RNA processing are impeded by two major problems: 1) The kinetics of the process must generally be inferred from steady-state levels of intermediates, so rapid processing events are essentially invisible, particularly if they occur cotranscriptionally. 2) The structures of RNA-protein... Read More →


Sunday September 23, 2012 1:15pm - 2:15pm
Agora 2

1:15pm

Meet the Speakers Lunch

Meet the keynote and plenary speakers. This is an ideal opportunity, especially for students and younger scientists, to meet the speaker faculty and ask questions.


Sunday September 23, 2012 1:15pm - 2:15pm
Agora 2

1:15pm

Satellite Symposium - Francis Crick Institute

Sunday September 23, 2012 13:15 - 14:15 @ Rhodes 6

 

In conversation with Paul Nurse – Director of the Francis Crick Institute, the new biomedical research institute opening in London in 2015. An opportunity to hear about the Crick and how it will work.

Website: www.crick.ac.uk

Twitter: @thecrick

Facebook: facebook.com/thefranciscrickinstitute

 


Speakers
avatar for Paul Nurse

Paul Nurse

Saturday September 22, 2012 17:45 - 18:30 @ Auditorium 


Sunday September 23, 2012 1:15pm - 2:15pm
Rhodes 6

1:30pm

Satellite Symposium - Cellectis bioresearch

Sunday 23 September, 2012 13:30-14:00 @  Rhodes 7

 

TALENs™: Next Generation Nucleases for Gene Knock-Out & Gene Modification throughout the Genome

Cellectis bioresearch will present the award-winning technology TALENs™ for Next Generation Genome Engineering: this tool can be used for precise gene knock-out (KO) and gene modification, at any position, in any genome, to generate both in vitro and in vivo models. In this presentation you will see recently obtained internal data on KOs and endogenous gene tagging experiments. Additionally will we show how we can support you in designing your experiments.


Exhibitors
avatar for Lars Knoch

Lars Knoch

Sales Manager Europe, Cellectis bioresearch
Genome editing in all its present possibilities and looking forward for future applications as well ... |


Sunday September 23, 2012 1:30pm - 2:00pm
Rhodes 7

2:30pm

Biological rhythms
Speakers
CD

Caroline Dean

John Innes Centre
Sunday September 23, 2012 15:15 - 15:45 @ Rhodes 6   Using seasonal temperature cues to ensure flowering in spring Abstract: Seasonal rhythms in flowering are the result of plants using photoperiodic and temperature cues to judge when to flower. Monitoring and integrating these environmental cues enables flowering to occur in favourable conditions so maximising reproductive success.  The acceleration of flowering by... Read More →
JF

Jean-Louis Franc

Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille
Sunday September 23, 2012 15:45 - 16:00 @ Rhodes 6    Paraspeckles display a circadian expression pattern in the somatolactotrope GH4C1 cell line Abstract: Paraspeckles are nuclear bodies built on a long non-coding RNA, Neat1, which assembles various protein components including the RNA-binding proteins NONO, SFPQ, PSPC1 and RBM14. Paraspeckles are believed to control gene expression through retention of A-to-I edited RNAs in... Read More →
LG

Lisa Gonçalves

Universidade do Algarve
Sunday September 23, 2012 15:00 - 15:15 @ Rhodes 6    Study of putative interactions between the embryo segmentation clock and molecular players of the circadian clock Abstract: Timing is essential for proper embryonic development. It has been shown the presence of periodic gene expression during embryogenesis, with a 90min period in somitogenesis and 6h in the limb, in the chick. These oscillations give the notion of time... Read More →
TK

Takao Kondo

Nagoya University
Sunday September 23, 2012 14:30 - 15:00 @ Rhodes 6    Circadian pacemaker and oscillator of cyanobacteria installed in KaiC protein Abstract: We reconstituted the self-sustained circadian oscillation in phosphorylation state of the cyanobacterial clock protein KaiC by incubating it with KaiA, KaiB, and ATP. This in vitro oscillation persisted robustly and the period was compensated against temperature changes.  As the KaiC... Read More →
US

Ueli Schibler

University of Geneva - Sciences II
Sunday September 23, 2012 16:00 - 16:30 @ Rhodes 6    Signaling within the mammalian circadian timing system Abstract: Cell-autonomous and self-sustained circadian oscillators are operative in virtually all body cells of mammalian organisms. These clocks are synchronized directly and indirectly by a master pacemaker residing in the suprachiasmatic nucleus (SCN) of the brain. Feeding rhythms (imposed by rest activity cycles... Read More →


Sunday September 23, 2012 2:30pm - 4:30pm
Rhodes 6

2:30pm

Cell polarity
Speakers
DA

Ditte Andersen

University of Nice-Sophia Antipolis
Sunday September 23, 2012 15:45 - 16:00 @ Auditorium    Identification of a previously uncharacterized transmembrane protein required for JNK-dependent neoplastic growth Abstract: Drosophila has emerged as a powerful model system for studying tumor growth. Drosophila epithelial structures (discs) bearing rasV12/scrib-/- mutant clones model several aspects of cancer in that mutant cells overgrow to generate tumor-like structures... Read More →
MG

Monica Gotta

University of Geneva
Sunday September 23, 2012 14:30 - 15:00 @ Auditorium    Asymmetric cell division and germline development Abstract: Establishment and maintenance of cell polarity are essential for many biological processes. In the C. elegans embryo the conserved PAR proteins regulate the cytoplasmic asymmetric localization of CCCH tandem zinc finger proteins (CCCH-proteins), which specify somatic and germ cell fates. MEX-5 and MEX-6, two... Read More →
MG

Markus Grebe

Umeå University
Sunday September 23, 2012 15:15 - 15:45 @ Auditorium    Modulation of cytoskeletal organization during planar polarity establishment in Arabidopsis Abstract: The coordination of cell polarity within the plane of a single tissue layer (planar polarity) is crucial to the development of multicellular organisms as diverse as animals and plants. We have established the root epidermis of Arabidopsis thaliana as a model system for... Read More →
TL

Thomas Lecuit

IBDML
Sunday September 23, 2012 16:00 - 16:30 @ Auditorium    Spatial control of cell mechanics during tissue morphogenesis Abstract: Tissues exhibit a remarkable dual property of robustness and plasticity. This relies on unique mechanical properties of the cell cortex and on adhesive interactions between cells. Our group seeks to understand the fundamental molecular mechanisms responsible for this property. This is essential to... Read More →
HL

Hyun Lee

Max Planck Institute for Molecular Cell Biology and Genetics
Sunday September 23, 2012 15:00 - 15:15 @ Auditorium    Interkinetic Nuclear Migration (IKNM) is regulated by Cdk1 and Rho kinase pathways in Zebrafish neuroepithelia Abstract: Pseudostratified epithelia are commonly found from Nematostella to humans, characterized by nuclei positioned along the entire length of the elongated cells. These nuclei migrate apically prior to division, and this so-called IKNM is crucial for tissue... Read More →


Sunday September 23, 2012 2:30pm - 4:30pm
Auditorium

2:30pm

Optogenetics & neuronal circuits
Speakers
HB

Herwig Baier

Max-Planck-Institut für Neurobiologie
Sunday September 23, 2012 14:30 - 15:00 @ Rhodes 7    Optogenetic dissection of the neural circuits that control eye movements in zebrafish Abstract: Eye movements have long been recognized as a relatively simple, stereotyped yet modifiable, behavior, which is controlled by sensory cues, particularly by visual and vestibular inputs. Pursuits of visual targets, as well as sudden shifts in gaze, or saccades, have been observed in... Read More →
KD

Karl Deisseroth

Stanford University
Sunday September 23, 2012 16:00 - 16:30 @ Rhodes 7    Development and application of optogenetics Abstract: Optogenetics, the combination of genetic and optical methods to control well-defined events in specific cells embedded within intact living tissue or organisms, has recently been applied to a number of neurological and psychiatric disease-related questions. Here we describe the use of microbial opsin genes to achieve... Read More →
NG

Nishith Gupta

Humboldt University
Sunday September 23, 2012 15:00 - 15:15 @ Rhodes 7    Optogenetic Modulation of cAMP Levels in the Obligate Intracellular Pathogen Toxoplasma gondii Abstract: Cyclic nucleotides (cAMP, cGMP) are ubiquitous and essential regulators of cellular signaling. The research on cyclic nucleotide signaling in intracellular pathogens relies on commercial modulators primarily targeting mammalian proteins. An unequivocal and inclusive... Read More →
OK

Ole Kiehn

Karolinska Institutet
Sunday September 23, 2012 15:15 - 15:45 @ Rhodes 7    Probing neural systems controlling locomotion Abstract: Brain functions are generated by activity in dedicated neural circuits. Understanding the function and operational mode of such circuits in the complex mammalian brain is fundamental for understanding the normal and the diseased brain. Locomotor behaviors, like walking, are selected and are initiated from supraspinal... Read More →
CD

Cristina De Luca

University of Rome Sapienza
Sunday September 23, 2012 15:45 - 16:00 @ Rhodes 7    Several identified photoreceptors in subterranean fungi Abstract: Light is detected through special molecules such as photoreceptors and used by the cell to regulate several different processes. This transduction has been mostly studied in the model system Neurospora crassa. To gain insight on photoreceptor systems we investigated the recently published genome of a... Read More →


Sunday September 23, 2012 2:30pm - 4:30pm
Rhodes 7

2:30pm

Organelle junctions & lipid transfer
Speakers
SE

Scott Emr

Weill Inst. for Cell and Molecular Biology & Dept. of Molecular Biology and Genetics, Cornell University
Sunday September 23, 2012 14:30 - 15:00 @ Rhodes 8    Regulation of phosphoinositide lipid signaling at organelle contact sites Abstract: Membrane contact sites are closely apposed regions between organelles implicated in intracellular signaling, lipid exchange, and calcium transport. Junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) where the peripheral ER underlies the PM as a network of sheets and... Read More →
EI

Elina Ikonen

University of Helsinki
Sunday September 23, 2012 16:00 - 16:30 @ Rhodes 8    Mechanisms of lipoprotein-derived lipid transfer in mammalian cells Abstract: Background: A major mechanism of lipid entry into mammalian cells is via receptor-mediated endocytosis of low-density lipoprotein (LDL)-particles. While LDL-receptors recycle to the plasma membrane for further cargo uptake the LDL-derived lipids are hydrolyzed in the acidic compartments... Read More →
LP

Laurent Pieuchot

Temasek Life Science Laboratory
Sunday September 23, 2012 15:00 - 15:15 @ Rhodes 8    Visualizing the peroxisomal protein import Abstract: Peroxisomes are ubiquitous eukaryotic organelles that have the remarkable ability to import folded and even oligomeric proteins. This distinguishes the import machinery from the well-characterized translocons of ER and mitochondria where proteins cross the membrane in an unfolded form. Despite successful identification... Read More →
LS

Luca Scorrano

University of Geneva Medical School
Sunday September 23, 2012 15:15 - 15:45 @ Rhodes 8  Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    Keeping the endoplasmic reticulum and mitochondria together Abstract: Mitochondria and endoplasmic reticulum (ER) are juxtaposed by specific molecular machinery that we are starting to unravel and that include mitofusin 2 (MFN2), a large mitochondrial GTPase that we identified as the first molecular... Read More →
AS

Alejandro Sodero

Katholieke Universiteit Leuven
Sunday September 23, 2012 15:45 - 16:00 @ Rhodes 8    Regulation of neuronal cholesterol content by glutamate/calcium-mediated CYP46A1 activation Abstract: The deregulation of brain cholesterol metabolism is typical in acute neuronal injury and chronic neurodegenerative diseases, and is paralleled by abnormal levels of the cholesterol metabolite 24S-hydroxycholesterol. Since both conditions are characterized by excessive... Read More →


Sunday September 23, 2012 2:30pm - 4:30pm
Rhodes 8

4:30pm

Poster Session A

Session A: Sunday 23 September 16:30 - 17:15 odd numbers, 17:15 - 18:00 even numbers @  Exhibition Hall 

 

EMBO Subject Areas:

Cellular Metabolism 
Chromatin & Transcription 
Genome Stability & Dynamics 
Immunology 
Microbiology, Virology & Pathogens 
RNA

 

Poster sessions are held on the Sunday, Monday and Tuesday in the exhibition hall.  Each session is 1.5 hours, the sessions will be split between odd and even poster numbers, so participants have 45 minutes to present their posters.

 

NOTE: Successful abstract submitters were notified on 24 August which poster session has been allocated to them. Due to the quantity of posters, it is not possible to change the allocated day.

Maximum recommended poster dimensions: 882 x 1,274mm (36" x 49.08") Portrait - DIN A0 Oversize Format.

The abstract book will be available online as a downloadable PDF two weeks prior to the conference to allow all registered participants to review abstracts and highlight posters of interest before arrival.  A printed abstract book will ONLY be available for you if you specify when registering that you would like one at a cost of €5.00. Some copies will be available for purchase onsite (subject to availability).

Please be aware that photographic recording of posters and other presentations is not permitted during the meeting.

Participants were invited to submit abstracts in the following research areas: read more

 

EMBO Scientific Publications poster prizes

The EMBO Editors are highlighting exceptional research presented by young researchers in the poster sessions at The EMBO Meeting. Each of the EMBO Scientific Publications (The EMBO JournalEMBO reportsMolecular Systems Biology and EMBO Molecular Medicine) will award a poster prize to their elected top poster exhibited at the conference. They will be looking for high quality and exciting unpublished research presented in a clear and appealing manner.

How to participate: Submit an abstract to The EMBO Meeting. Your poster will be automatically considered if accepted.

Selections: Selections will be made by the editors  and members of the EMBO Young Investigator Programme and EMBO Installation Grantees based on the abstracts and during the poster sessions.

Prize: Voucher (value: €250) to be used towards the registration fee to any EMBO Course, Workshop or Conference of your choice in 2014.

The awards will be announced and presented during the closing ceremony.


Sunday September 23, 2012 4:30pm - 6:00pm
Exhibition Hall

6:00pm

A forgotten world: The living ocean - Eric Karsenti

Special lecture

Abstract:

The first forms of life (bacteria-like particles) date back to 3.8 billions years, 1.3 billion years after the birth of our planet. Since then most forms of life have been found in the oceans for billions years before appearing on land. In fact, most of the important evolutionary steps that led to complex mammals on land later on, like multicellularisation, bilateralisation, skeleton formation body plan genes, first appeared in organisms living in the oceans.  This oceanic life, in turn changed the chemistry of our atmosphere, removing most of CO2 (the original earth atmosphere was anoxic and contained more than 90% CO2) and producing oxygen through photosynthesis, allowing the eventual emergence of placental organisms. Natural selection is but one of the many parameters that drove evolution of life on earth, especially in the oceans where the whole thing started. Symbiosis, altruism, collaborative and collective behaviors, genome exchanges and complex adaptations within large ecosystems are as important. Over billions years, the chemistry, climate, geology of earth have been co-evolving with living organisms and most of this happened in the Oceans. I will show what we know today about this beautiful story and how we are trying to better understand it, using the modern tools of molecular biology and large scale expeditions.

 


Speakers
avatar for Dr. Eric Karsenti

Dr. Eric Karsenti

Group Leader and Senior Scientist in EMBL, Co-Director of Tara Oceans, EMBL, Cell Biology & Biophysics Unit
Sunday September 23, 2012 18:00 - 19:00 @ Auditorium 
avatar for Maria Leptin

Maria Leptin

EMBO Director, EMBO


Sunday September 23, 2012 6:00pm - 7:00pm
Auditorium

7:00pm

EMBO Gold Medal Award Ceremony

The EMBO Gold Medal 2012 has been awarded to Jiří Friml of the Department of Plant Systems Biology, VIB and Ghent University, Belgium and Central European Institute of Technology, University Brno, Czech Republic.

 

Awarded annually, the EMBO Gold Medal recognizes outstanding contributions of young researchers in the molecular life sciences.

 

The recipient is awarded the Medal at The EMBO Meeting and gives a talk.

 


Speakers
AB

Anton Berns

Secretary General of EMBO, Netherlands Cancer Institute
avatar for Jiří Friml

Jiří Friml

VIB & Gent University | Central European Institute of Technology, University Brno
Sunday September 23, 2012 19:00 - 19:45 @ Auditorium    Auxin transport – connecting cell polarity and patterning Abstract: Auxin is a prominent intercellular signal in plants and acts as a versatile trigger of developmental change. Directional, active, cell-to-cell transport over short distances mediates differential auxin distributions within tissues (auxin gradients) that are required for various patterning... Read More →


Sunday September 23, 2012 7:00pm - 7:45pm
Auditorium

8:00pm

PhD meets Postdoc Party

Sunday September 23, 2012 20:00-22:00 @ Valrose Campus Nice Sophia-Antipolis University (tram T1 to Valrose Université)

 

Organized and hosted by BDE bio – biology student association Valrose campus, University Nice Sophia Antipolis.

 


Sunday September 23, 2012 8:00pm - 10:00pm
Valrose Campus Nice Sophia-Antipolis University
 
Monday, September 24
 

9:00am

Nutrient-sensing pathways and ageing - Linda Partridge

Keynote Lecture

Abstract:

Research into ageing has been rejuvenated by the discovery that mutations
in single genes can increase healthy lifespan in laboratory model
organisms. The nutrient-sensing insulin/insulin-like growth factor/TOR
signalling network has thus been found to have a role in ageing that is
conserved from yeast to mammals, possibly including humans. Extension of
lifespan is accompanied by an increase in health and function at later
ages, and manipulation of this signalling network can also reduce the
pathology associated with genetic models of human ageing-related diseases.
This talk will discuss the mechanisms at work and their potential
relevance to humans.

 


Speakers
AB

Anton Berns

Secretary General of EMBO, Netherlands Cancer Institute
avatar for Linda Partridge

Linda Partridge

Max-Planck-Institute for the Biology of Ageing & University College London
Monday September 24, 2012 09:00 - 09:45 @ Auditorium 


Monday September 24, 2012 9:00am - 9:45am
Auditorium

9:45am

Louis-Jeantet Prize Lectures by Matthias Mann & Fiona Powrie
Speakers
avatar for Matthias Mann

Matthias Mann

Max Planck Institute of Biochemistry
Monday September 24, 2012 09:45 - 10:45 @ Auditorium    Near comprehensive proteome characterization and its applications in cell biology and cancer research Abstract: The promise of proteomics as a component of systems wide investigation in biology has been obvious for a long time. However, it has only been in the last few years that mass spectrometry has successfully met the technological challenges associated... Read More →
avatar for Fiona Powrie

Fiona Powrie

Nuffield Department of Clinical Medicine, University of Oxford
Monday September 24, 2012 09:45 - 10:45 @ Auditorium    Gut reactions: Immune pathways in the intestine in health and disease Abstract: The gastrointestinal (GI) tract is home to a large number and vast array of bacteria that play an important role in nutrition, immune system development and host defense. In inflammatory bowel disease (IBD) there is a breakdown in this mutualistic relationship resulting in aberrant inflammatory... Read More →
BR

Bernard Rossier

Secretary of the Scientific Committee, Louis-Jeantet Foundation


Monday September 24, 2012 9:45am - 10:45am
Auditorium

10:45am

Break
Monday September 24, 2012 10:45am - 11:15am
TBA

11:15am

Causes & consequences of aneuploidy
Speakers
AA

Angelika Amon

Massachusetts Institute of Technology
Monday September 24, 2012 12:45 - 13:15 @ Auditorium    Aneuploidy causes proteotoxic stress Abstract: Aneuploidy is defined as a chromosome number that is not a multiple of the haploid complement. Although it has been known for a long time that the condition is associated with many human diseases including cancer, how the condition affects organismal and cellular physiology has until recently not been studied. We have... Read More →
RJ

Rolf Jessberger

Dresden University of Technology
Monday September 24, 2012 12:00 - 12:30 @ Auditorium    Properties and Functions of Cohesin in Mammalian Meiosis Abstract: The canonical cohesin complex consists of SMC1, SMC3, and a kleisin, which form a tripartite ring. Additional proteins such as SA, WAPL, PDS5B, Sororin or an acetyl transferase (ECO1/2) interact with the complex. Mammalian meiocytes form several different, spatiotemporally distinct cohesin complexes, for... Read More →
AK

Anastasia Kuznetsova

Max Planck Institute of Biochemistry
Monday September 24, 2012 12:30 - 12:45 @ Auditorium    Transient tetraploidy paves the way to aneuploidy and chromosomal instability by enhancing survival after chromosome segregation errors Abstract: Aneuploidy, defined as alterations in both chromosome number and structure, and chromosomal instability (CIN) are hallmarks of solid tumors. Growing evidence suggests that aneuploidy facilitates carcinogenesis in both mice and... Read More →
EA

Erich A. Nigg

Biozentrum, University of Basel
Monday September 24, 2012 11:15 - 11:45 @ Auditorium    Control of accurate chromosome segregation during mitosis: Aurora B regulates kinetochore-microtubule interactions through phosphorylation of the tripartite Ska complex Abstract: The error-free segregation of duplicated chromosomes during cell division is critical for the development and health of all organisms. Central to chromosome segregation is the mitotic spindle... Read More →
MS

Matthias Samwer

Max Planck Institute for Biophysical Chemistry
Monday September 24, 2012 11:45 - 12:00 @ Auditorium   A novel actin-bundling kinesin that is essential for meiotic cell division Abstract: F-actin networks are involved in many important cellular functions. Dozens of accessory proteins modulate these networks and facilitate their adaptation to specific requirements. Many key constituents of cytoplasmic F-actin networks have been identified and studied in detail. However, there is... Read More →


Monday September 24, 2012 11:15am - 1:15pm
Auditorium

11:15am

DNA replication & repair
Speakers
JD

John Diffley

London Research Institute
Monday September 24, 2012 11:15 - 11:45 @ Rhodes 6    Early Events in Eukaryotic DNA Replication Abstract: The eukaryotic cell cycle coordinates the accurate duplication and segregation of the genome during proliferation. The large genomes of eukaryotic cells are replicated from multiple replication origins during S phase. These origins are not activated synchronously at the beginning of S phase, but instead fire throughout S... Read More →
EF

Eric Fischer

Friedrich Miescher Institute for Biomedical Research
Monday September 24, 2012 12:30 - 12:45 @ Rhodes 6   The molecular basis of CRL4(DDB2/CSA) ubiquitin ligase architecture, targeting to chromatin, and COP9 signalosome mediated activation Abstract: The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 serves in the initial recognition of UV-induced DNA damages such as 6-4... Read More →
MH

Michael Harris

University College London
Monday September 24, 2012 11:45 - 12:00 @ Rhodes 6    Linking DNA replication checkpoint to cell-cycle transcription reveals a distinct class of G1/S genes Abstract: Replication-induced stress leads to a cellular response to prevent DNA damage and maintain genome integrity. An important part of this response is at the transcriptional level where genes involved in DNA damage repair (DDR) and cell cycle (CC) regulated genes are... Read More →
CK

Caroline Kisker

Universität Würzburg
Monday September 24, 2012 12:00 - 12:30 @ Rhodes 6    Towards damage verification in nucleotide excision repair Abstract: DNA damage recognition by the nucleotide excision repair pathway requires the division of labour into a scanning step identifying helical distortions in the DNA and a proofreading step verifying the presence of a lesion. This proofreading step can be accomplished in eukaryotes by the ten subunit containing... Read More →
PS

Primo Schär

University of Basel, Institute of Biochemistry and Genetics
Monday September 24, 2012 12:45 - 13:15 @ Rhodes 6    DNA Repair and the Dynamics of Cytosine Methylation Abstract: The thymine DNA glycosylase (TDG) is a DNA repair enzyme directed against a broad range of damaged bases in DNA, including the oxidation and deamination products of cytosine and 5-methylcytosine (5-meC). Although this implicates a biological function in mutation avoidance, the phenotype of a Tdg knockout mouse... Read More →


Monday September 24, 2012 11:15am - 1:15pm
Rhodes 6

11:15am

Genes to shape
Speakers
avatar for Markus Affolter

Markus Affolter

Biozentrum, University of Basel
Monday September 24, 2012 12:00 - 12:30 @ Rhodes 7    Cell behavior in angiogenesis Abstract: To form interconnected networks of endothelial tubes, sprouting vessels of the developing vasculature have to connect to each other, a process referred to as anastomosis. To better understand cell behavior during anastomosis, we studied how angiogenic sprouts connect to give rise to a fully lumenized vessel (DLAV) in different... Read More →
FB

Floris Bosveld

Institut Curie
Monday September 24, 2012 11:45 - 12:00 @ Rhodes 7    Mechanical control of tissue morphogenesis by the Fat/Dachsous/Four-jointed planar cell polarity pathway Abstract: During animal development, several planar cell polarity (PCP) pathways control tissue shape by coordinating collective cell behavior. Recent studies implicated cell tension as a regulator of convergence extension movement, the physical separation of... Read More →
EC

Enrico Coen

John Innes Centre
Monday September 24, 2012 11:15 - 11:45 @ Rhodes 7    A Framework for Tissue Cell Polarity in Plants and Animals Abstract: Development involves highly oriented cell behaviours, such as anisotropic growth and asymmetric cell divisions.  It is unclear how these orientations are specified and coordinated over extended tissue domains. We have been addressing this problem through computer simulations of cell polarity... Read More →
avatar for Brigid L.M. Hogan

Brigid L.M. Hogan

Duke University Medical Center
Monday September 24, 2012 12:45 - 13:15 @ Rhodes 7    Lung stem cells and their role in tissue homeostasis and repair Abstract: The Hogan lab is studying the epithelial stem cells in different regions of the lung – the large and small airways, and the millions of alveoli in the distal region where gas exchange takes place. In each region, stem cells play critical roles in maintaining the physical integrity, polarity and... Read More →
avatar for Denis Menshykau

Denis Menshykau

PostDoc, ETH Zurich
Monday September 24, 2012 12:30 - 12:45 @ Rhodes 7  |   | | Computational Models of Lung and Kidney Branching Morphogenesis | | Abstract: | | Many organs of higher organisms, such as lung, kidney, and glands, are heavily branched structures. The branching process during kidney and lung development is remarkably stereotyped. The branched trees of lungs and kidneys are generated by the sequential, non-random use of... Read More →


Monday September 24, 2012 11:15am - 1:15pm
Rhodes 7

11:15am

The neuronal synapse
Speakers
JA

José Antonio Esteban García (CANCELLED)

Centro de Biología Molecular “Severo Ochoa” (CBMSO)
CANCELLED
AG

Anibal Garza Carbajal

Universitätsklinik Köln | Max-Planck-Institute for Molecular Genetics
Monday September 24, 2012 11:45 - 12:00 @ Rhodes 8   Differential regulation of the Erk pathway in sensory neurons and glia: A high content microscopy approach Abstract: Contrary to other cellular models, the signaling networks underlying sensitization in primary sensory neurons are only starting to be explored. A simple transfer of knowledge from one cell type to another is tempting, but not always valid. Here, we... Read More →
EM

Erik M. Jorgensen

University of Utah
Monday September 24, 2012 11:15 - 11:45 @ Rhodes 8    Revisiting Heuser and Reese: ultrafast endocytosis at C. elegans synapses  Abstract: To sustain high rates of release, synaptic vesicles must be recycled locally at a synapse. There are two major models for the recovery of synaptic vesicles: clathrin-mediated endocytosis and kiss-and-run endocytosis.   We have developed a method to stimulate an intact nematode and... Read More →
ZR

Ziv Rotman

Washington University
Monday September 24, 2012 12:30 - 12:45 @ Rhodes 8   Motion dynamics of synaptic vesicle populations at nanometer resolution Abstract: Most central synapses contain a very small number of release-competent vesicles. Synaptic function thus critically depends on an efficient vesicle recycling program to sustain and control neurotransmitter release. Despite several decades of research on synaptic function, the basic vesicle cycling... Read More →
SS

Stephan Sigrist

Institute of Biology, Free University Berlin & NeuroCure
Monday September 24, 2012 12:00 - 12:30 @ Rhodes 8   Shedding light on the assembly of synapse structure and function Abstract: The majority of rapid cell-to-cell communication mechanisms and information processing within the nervous system makes use of chemical synapses. Thereby, the molecular organization of presynaptic active zones, the places where neurotransmitter filled synaptic vesicles get released, is a focus of intense... Read More →


Monday September 24, 2012 11:15am - 1:15pm
Rhodes 8

1:15pm

Break
Monday September 24, 2012 1:15pm - 3:00pm
TBA

1:30pm

Satellite Symposium - Carl Zeiss Microscopy

Monday September 24, 2012 13:30 - 14:00Rhodes 6 


Monday September 24, 2012 1:30pm - 2:00pm
Rhodes 6

1:30pm

Meet the Speakers Lunch

Monday September 24, 2012 13:30 - 14:30Agora 2 

 

Meet the keynote and plenary speakers. This is an ideal opportunity, especially for students and younger scientists, to meet the speaker faculty and ask questions.


Speakers
SE

Scott Emr

Weill Inst. for Cell and Molecular Biology & Dept. of Molecular Biology and Genetics, Cornell University
Sunday September 23, 2012 14:30 - 15:00 @ Rhodes 8    Regulation of phosphoinositide lipid signaling at organelle contact sites Abstract: Membrane contact sites are closely apposed regions between organelles implicated in intracellular signaling, lipid exchange, and calcium transport. Junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) where the peripheral ER underlies the PM as a network of sheets and... Read More →
avatar for Jiří Friml

Jiří Friml

VIB & Gent University | Central European Institute of Technology, University Brno
Sunday September 23, 2012 19:00 - 19:45 @ Auditorium    Auxin transport – connecting cell polarity and patterning Abstract: Auxin is a prominent intercellular signal in plants and acts as a versatile trigger of developmental change. Directional, active, cell-to-cell transport over short distances mediates differential auxin distributions within tissues (auxin gradients) that are required for various patterning... Read More →
avatar for Dr. Eric Karsenti

Dr. Eric Karsenti

Group Leader and Senior Scientist in EMBL, Co-Director of Tara Oceans, EMBL, Cell Biology & Biophysics Unit
Sunday September 23, 2012 18:00 - 19:00 @ Auditorium 
avatar for Matthias Mann

Matthias Mann

Max Planck Institute of Biochemistry
Monday September 24, 2012 09:45 - 10:45 @ Auditorium    Near comprehensive proteome characterization and its applications in cell biology and cancer research Abstract: The promise of proteomics as a component of systems wide investigation in biology has been obvious for a long time. However, it has only been in the last few years that mass spectrometry has successfully met the technological challenges associated... Read More →
avatar for Linda Partridge

Linda Partridge

Max-Planck-Institute for the Biology of Ageing & University College London
Monday September 24, 2012 09:00 - 09:45 @ Auditorium 
avatar for Fiona Powrie

Fiona Powrie

Nuffield Department of Clinical Medicine, University of Oxford
Monday September 24, 2012 09:45 - 10:45 @ Auditorium    Gut reactions: Immune pathways in the intestine in health and disease Abstract: The gastrointestinal (GI) tract is home to a large number and vast array of bacteria that play an important role in nutrition, immune system development and host defense. In inflammatory bowel disease (IBD) there is a breakdown in this mutualistic relationship resulting in aberrant inflammatory... Read More →


Monday September 24, 2012 1:30pm - 2:30pm
Agora 2

1:30pm

Pursuing an Academic Career

Monday September 24, 2012 13:30 - 15:00Gallieni 1 & Gallieni 2

 

The EMBO Meeting speaker faculty will facilitate discussion, answer questions and recommend appropriate resources on a variety of topics related to careers in academia.

Please note spaces at the Pursuing an academic career session are limited. This is already full and registration is closed.

Up to ten participants and two mentors will be seated for round table discussions per topic:

1. After your PhD - what comes next in academia? The choice between a postdoc in your home country or abroad, Europe, the USA or elsewhere?
a) Facilitators: François Nédélec & Luca Scorrano
b) Facilitators: Eduardo Moreno & Dirk Schübeler

2. Planning your career: obtaining an appropriate postdoc position
Facilitators: Caroline Kisker & Elina Ikonen

3. Starting your own lab: where and how (i.e. tenured positions, fellowships, grants) and other issues
Facilitators: Markus Grebe & Angel Nebreda

4. Job application strategies for academic positions: applying for independent positions - first as a junior independent investigator and then at higher (assistant professor) level
Facilitators: Matthias Hentze & Howard Riezman

5. Defining and refining research directions for your project and your group
Facilitators: John Diffley & Jean-Paul Vincent

6. Raising a family while pursuing a career in research
Facilitators: Monica Gotta & Thomas Lecuit

7. Publishing: How important is it for your career? When is your story ready to be published? Which journal to try? Who should be involved in writing the paper, and who should be co-authors? How to reply to editors and reviewers?
Facilitators: Caroline Dean & Michael Way

8. Writing your first grant. Grant opportunities for young scientists within Europe
Facilitators: Erez Raz & Andrea Musacchio

9. Communicating your science
Facilitators: Enrico Coen & Mónica Bettencourt-Dias


Speakers
MB

Mónica Bettencourt-Dias

The Instituto Gulbenkian de Ciência (IGC)
Monday September 24, 2012 15:00 - 15:30 @ Rhodes 7  Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    BLD10/CEP135 is a microtubule-­‐associated protein that controls the formation of the flagellum central microtubule pair Abstract: Cilia and flagella are structures involved in a variety of developmental processes and human diseases, including ciliopathies and sterility. We investigate how the... Read More →
EC

Enrico Coen

John Innes Centre
Monday September 24, 2012 11:15 - 11:45 @ Rhodes 7    A Framework for Tissue Cell Polarity in Plants and Animals Abstract: Development involves highly oriented cell behaviours, such as anisotropic growth and asymmetric cell divisions.  It is unclear how these orientations are specified and coordinated over extended tissue domains. We have been addressing this problem through computer simulations of cell polarity... Read More →
CD

Caroline Dean

John Innes Centre
Sunday September 23, 2012 15:15 - 15:45 @ Rhodes 6   Using seasonal temperature cues to ensure flowering in spring Abstract: Seasonal rhythms in flowering are the result of plants using photoperiodic and temperature cues to judge when to flower. Monitoring and integrating these environmental cues enables flowering to occur in favourable conditions so maximising reproductive success.  The acceleration of flowering by... Read More →
JD

John Diffley

London Research Institute
Monday September 24, 2012 11:15 - 11:45 @ Rhodes 6    Early Events in Eukaryotic DNA Replication Abstract: The eukaryotic cell cycle coordinates the accurate duplication and segregation of the genome during proliferation. The large genomes of eukaryotic cells are replicated from multiple replication origins during S phase. These origins are not activated synchronously at the beginning of S phase, but instead fire throughout S... Read More →
MG

Monica Gotta

University of Geneva
Sunday September 23, 2012 14:30 - 15:00 @ Auditorium    Asymmetric cell division and germline development Abstract: Establishment and maintenance of cell polarity are essential for many biological processes. In the C. elegans embryo the conserved PAR proteins regulate the cytoplasmic asymmetric localization of CCCH tandem zinc finger proteins (CCCH-proteins), which specify somatic and germ cell fates. MEX-5 and MEX-6, two... Read More →
MG

Markus Grebe

Umeå University
Sunday September 23, 2012 15:15 - 15:45 @ Auditorium    Modulation of cytoskeletal organization during planar polarity establishment in Arabidopsis Abstract: The coordination of cell polarity within the plane of a single tissue layer (planar polarity) is crucial to the development of multicellular organisms as diverse as animals and plants. We have established the root epidermis of Arabidopsis thaliana as a model system for... Read More →
MW

Matthias W. Hentze

EMBL
Monday September 24, 2012 15:45 - 16:15 @ Rhodes 8   Insights into RNA biology from eukaryotic cell mRNA interactomes Abstract: RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV-crosslinking of RBPs to RNA, we have used a systematic, unbiased and comprehensive approach to define the mRNA interactome of proliferating human HeLa cells. Of the proteins captured... Read More →
EI

Elina Ikonen

University of Helsinki
Sunday September 23, 2012 16:00 - 16:30 @ Rhodes 8    Mechanisms of lipoprotein-derived lipid transfer in mammalian cells Abstract: Background: A major mechanism of lipid entry into mammalian cells is via receptor-mediated endocytosis of low-density lipoprotein (LDL)-particles. While LDL-receptors recycle to the plasma membrane for further cargo uptake the LDL-derived lipids are hydrolyzed in the acidic compartments... Read More →
CK

Caroline Kisker

Universität Würzburg
Monday September 24, 2012 12:00 - 12:30 @ Rhodes 6    Towards damage verification in nucleotide excision repair Abstract: DNA damage recognition by the nucleotide excision repair pathway requires the division of labour into a scanning step identifying helical distortions in the DNA and a proofreading step verifying the presence of a lesion. This proofreading step can be accomplished in eukaryotes by the ten subunit containing... Read More →
TL

Thomas Lecuit

IBDML
Sunday September 23, 2012 16:00 - 16:30 @ Auditorium    Spatial control of cell mechanics during tissue morphogenesis Abstract: Tissues exhibit a remarkable dual property of robustness and plasticity. This relies on unique mechanical properties of the cell cortex and on adhesive interactions between cells. Our group seeks to understand the fundamental molecular mechanisms responsible for this property. This is essential to... Read More →
avatar for Eduardo Moreno

Eduardo Moreno

Institute of Cell Biology, University of Bern
Sunday September 23, 2012 12:30 - 13:00 @ Rhodes 6   Cellular fitness from Drosophila to mammals Abstract: I will describe the molecules and mechanisms through which animal cells reveal their fitness to the neighboring cells within tissues. The conserved roles of the "Flower Code" and Sparc in Drosophila and mammals will be discussed. Finally I will highlight the connections between the molecular determinants that reveal and... Read More →
AM

Andrea Musacchio

MPI für molekulare Physiologie
Monday September 24, 2012 16:30 - 17:00 @ Rhodes 7    The persuasive biochemical logic of kinetochores Abstract: The main focus of our laboratory is the reconstitution of kinetochores, and of their dynamic interactions with the spindle assembly checkpoint. Kinetochores are large proteinaceous disks that are built on centromeric DNA. In mitosis, they provide a site of attachment of chromosomes to the mitotic spindle. The spindle... Read More →
AR

Angel R. Nebreda

Institute for Research in Biomedicine (IRB)
Monday September 24, 2012 16:30 - 17:00 @ Auditorium    p38 MAPK signaling in tumorigenesis Abstract: The p38α MAP kinase pathway plays key roles in the cellular responses to stress but can also integrate signals that affect many other cellular processes in a cell context-specific and cell type-specific manner. Studies using genetically modified mice have elucidated some in vivo functions for p38α, and provided... Read More →
FN

François Nédélec

EMBL, Structural and Computational Biology
Monday September 24, 2012 15:45 - 16:15 @ Rhodes 7   Design principles of yeast spindles Abstract: Bundled cytoskeletal arrays are a universal feature of eukaryotic cells. The anaphase B spindle from fission yeast serves as an excellent model system for studying cytoskeletal arrays under compressive forces as it can be perturbed genetically, is easily visualized using electron or light microscopy and has an organization that is... Read More →
ER

Erez Raz

Institute of Cell Biology, ZMBE
Sunday September 23, 2012 11:00 - 11:30 @ Rhodes 7    Motility and guided migration of zebrafish Primordial Germ Cells Abstract: The migration of Primordial Germ Cells in zebrafish serves as a model for single-cell migration in development, homeostasis, and disease. We use this model to investigate the basic cellular mechanisms directing cells into motile behavior and those allowing the cells to respond to directional cues. We... Read More →
HR

Howard Riezman

University of Geneva - Sciences II
Sunday September 23, 2012 11:45 - 12:15 @ Rhodes 8    Systematic lipidomic analysis of yeast mutants reveals novel regulation of lipid homeostasis and plasma membrane/ER communication Abstract: We have performed an unbiased, systematic, lipidomics analysis of two collections of yeast mutants ; in the early secretory pathway previously used for an epistatic miniarray profiling (Schuldiner et al, 2005) and a collection of yeast... Read More →
DS

Dirk Schübeler

Friedrich Miescher Institute
Sunday September 23, 2012 11:45 - 12:15 @ Auditorium    DNA sequence determinants of gene repression Abstract: Chromatin and DNA modifications have emerged as a critical component for gene regulation in higher eukaryotes yet how these epigenetic variables are targeted to specific sites of the genome is still poorly understood. We have generated global maps of DNA methylation, histone modifications and replication in higher... Read More →
LS

Luca Scorrano

University of Geneva Medical School
Sunday September 23, 2012 15:15 - 15:45 @ Rhodes 8  Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    Keeping the endoplasmic reticulum and mitochondria together Abstract: Mitochondria and endoplasmic reticulum (ER) are juxtaposed by specific molecular machinery that we are starting to unravel and that include mitofusin 2 (MFN2), a large mitochondrial GTPase that we identified as the first molecular... Read More →
JV

Jean-Paul Vincent

Division of Developmental Neurobiology
Sunday September 23, 2012 11:45 - 12:15 @ Rhodes 6   Death, survival and Wingless signalling in developing wing imaginal discs of Drosophila Abstract: Epithelia have evolved several quality control mechanisms that lead to the elimination of defective or mis-specified cells. The widespread apoptosis that occurs following epithelial disruption provides an extreme example. I will describes our studies aimed at delineating the... Read More →
MW

Michael Way

London Research Institute
Tuesday September 25, 2012 09:45 - 10:15 @ Rhodes 6    WIP links Nck to N-WASP during Arp2/3 complex dependent actin polymerization Abstract: Activation of Arp2/3 complex dependent actin polymerization by Nck and N-WASP/WASP signalling networks plays an important role during a variety of cellular processes, including endocytosis, phagocytosis and invadopodia formation.  Unfortunately, during its egress vaccinia virus... Read More →


Monday September 24, 2012 1:30pm - 3:00pm
Gallieni 1

1:30pm

Satellite Symposium - Leica Microsystems

Monday September 24, 2012 13:30 - 15:00Rhodes 7 

 

Part 1 : Leica TCS SP8 : Looking forward to your discoveries 

With the Leica TCS SP8 Leica presents its new confocal platform for high-speed 4D imaging, multispectral sensitivity and upgradability into any confocal imaging modality including multiphoton excitation, CARS imaging, single molecule detection and high content screening. The presentation will focus on how the Leica TCS SP8 accelerates confocal imaging thus paving the way for new applications with video-rate confocal imaging and saving time on large scale imaging projects. The second focus is on super-sensitive detection and new optics for maximal photon efficiency and sample viability, including the second generation white light laser with the unique Lightgate techonology for informative imaging. 

Part 2 : Leica TCS SP8 gated STED : Opening the gate to the super-resolution 

After enabling multi-color confocal nanoscopy on the Leica TCS STED and the Leica TCS STED CW, Leica Microsystems now presents the next milestone in confocal super-resolution. Stimulated emission depletion (STED) microscopy provides fast and easy access to resolutions far beyond the Abbe limit. Gated STED is a new further development of STED microscopy . It combines STED with CW lasers and time gated detection and this way increases resolution as well as photo stability significantly.


Exhibitors

Monday September 24, 2012 1:30pm - 3:00pm
Rhodes 7

2:15pm

Satellite Symposium - Cellecta

Monday September 24, 2012 14:15 - 14:45Rhodes 6 

 

Phenotypic loss-of-function RNAi screens with complex lentiviral-based shRNA expression libraries that target and silence several thousand genes provide a realistic and workable approach to identify genes that functionally modulate a cellular response such as viability of cancer cells or apoptosis.  As long as the shRNA libraries are properly constructed so that hairpin representation is well characterized and reasonably constrained, and changes in shRNA representation in selected vs. control cell populations can be efficiently measured by HT sequencing, pooled RNAi screens produce robust and reproducible results in a range of cell models.

We will present results from two analyses: one “drop-out” screen to identify genes essential for viability in a panel of leukemic cells, and a second “rescue” screen to identify genes required for FAS‑induced apoptosis.  Both screens found a combination of known and novel signaling pathway and regulatory genes whose functions were confirmed to be required to produce the biological responses.  In the case of the FAS-induced apoptosis, in vitro screening data also enabled us to select targets that protected mice from FAS-induced hepatic failure.  These results demonstrate that complex pooled shRNA libraries provide a highly efficient, flexible, and cost-effective alternative to array-based RNAi screening methods for identifying genes regulating biological responses and possible new therapeutic targets.

 

More information: http://www.cellecta.com/products-services/RNAi-genetic-screens/ 

Blog: http://www.cellecta.com/blog

Twitter: @CELLECTA


Exhibitors

Monday September 24, 2012 2:15pm - 2:45pm
Rhodes 6

3:00pm

Genetic diversity
Speakers
RD

Richard Durbin

Wellcome Trust Sanger Institute
Monday September 24, 2012 15:00 - 15:30 @ Rhodes 6   Human genetic variation: from population sequencing to cellular function Abstract: The dramatic decrease in DNA sequencing costs in the last few years has allowed direct full genome sequence studies of genetic diversity by sequencing multiple individuals.  As well supporting evolutionary and population genetic studies, this also allows phenotype association studies to be... Read More →
MN

Magnus Nordborg

Gregor Mendel Institute of Molecular Plant Biology
Monday September 24, 2012 16:30 - 17:00 @ Rhodes 6   Natural variation in Arabidopsis: insights from the 1,001 Genomes Project Abstract: The common weed Arabidopsis thaliana is highly selfing and naturally exists as locally adapted inbred lines that can readily be grown in replicate under controlled conditions.  This makes it an excellent model for studying the genetics of natural variation, and, indeed, shared inbred lines... Read More →
MP

Molly Przeworski

Howard Hughes Medical Institute
Monday September 24, 2012 15:45 - 16:15 @ Rhodes 6    When ancestry runs deep: trans-species polymorphisms in apes Abstract: Balancing selection refers to the maintenance of more than one allele in the population for an unusually long time. In cases where balancing selection pressures have existed for millions of years, different species can share the same polymorphism identical by descent, resulting in a trans-species... Read More →
MW

Maria Warnefors

University of Lausanne
Monday September 24, 2012 16:15 - 16:30 @ Rhodes 6    Correlated patterns of gene expression divergence and protein evolution in mammals Abstract: Divergence of protein sequences and gene expression patterns are two fundamental mechanisms that generate organismal diversity. Here we use genome and transcriptome data from eight mammalian species and one bird outgroup to study the evolutionary relationships between these two... Read More →
DW

David Wood

University of Queensland
Monday September 24, 2012 15:30 - 15:45 @ Rhodes 6    Are Tissue-Restricted Genes More Likely To Show Imbalanced Allelic Expression? Abstract: Allelic Specific Expression (ASE) is a process where RNA transcribed from parental alleles differs in abundance or form. ASE can involve near-complete suppression of expression, as in X-inactivation and imprinting, or imbalanced expression, through polymorphisms modulating... Read More →


Monday September 24, 2012 3:00pm - 5:00pm
Rhodes 6

3:00pm

Microtubule cytoskeleton
Speakers
MB

Mónica Bettencourt-Dias

The Instituto Gulbenkian de Ciência (IGC)
Monday September 24, 2012 15:00 - 15:30 @ Rhodes 7  Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    BLD10/CEP135 is a microtubule-­‐associated protein that controls the formation of the flagellum central microtubule pair Abstract: Cilia and flagella are structures involved in a variety of developmental processes and human diseases, including ciliopathies and sterility. We investigate how the... Read More →
AM

Andrea Musacchio

MPI für molekulare Physiologie
Monday September 24, 2012 16:30 - 17:00 @ Rhodes 7    The persuasive biochemical logic of kinetochores Abstract: The main focus of our laboratory is the reconstitution of kinetochores, and of their dynamic interactions with the spindle assembly checkpoint. Kinetochores are large proteinaceous disks that are built on centromeric DNA. In mitosis, they provide a site of attachment of chromosomes to the mitotic spindle. The spindle... Read More →
FN

François Nédélec

EMBL, Structural and Computational Biology
Monday September 24, 2012 15:45 - 16:15 @ Rhodes 7   Design principles of yeast spindles Abstract: Bundled cytoskeletal arrays are a universal feature of eukaryotic cells. The anaphase B spindle from fission yeast serves as an excellent model system for studying cytoskeletal arrays under compressive forces as it can be perturbed genetically, is easily visualized using electron or light microscopy and has an organization that is... Read More →
avatar for Iva Tolic-Norrelykke

Iva Tolic-Norrelykke

Max Planck Institute of Molecular Cell Biology and Genetics
Monday September 24, 2012 16:15 - 16:30 @ Rhodes 7    Dynein switches from diffusion along the microtubule to directed movement upon binding to the cortex: a single-molecule in vivo study Abstract: Cytoplasmic dynein is a motor protein that walks along microtubules and in doing so positions organelles in the cell. Dynein uses microtubules either as tracks to transport organelles, proteins and RNAs, or as ropes to pull on... Read More →
CV

Catarina Vicente

University of Oxford
Monday September 24, 2012 15:30 - 15:45 @ Rhodes 7   Elucidating the pathway of centrosome formation in Drosophila Abstract: Centrosomes are cellular organelles that comprise two centrioles surrounded by pericentriolar material (PCM). Although a conserved core set of proteins that are required for centriole duplication and PCM recruitment have been identified in Drosophila, little is known about their order of recruitment. This is... Read More →


Monday September 24, 2012 3:00pm - 5:00pm
Rhodes 7

3:00pm

Post-transcriptional control of gene expression
Speakers
JA

José Andrade

Universidade Nova de Lisboa
Monday September 24, 2012 15:30 - 15:45 @ Rhodes 8   Important factors in small RNA degradation: contrasting roles of PNPase and Hfq in the regulation of small RNAs Abstract: Bacterial small RNAs (sRNAs) are extremely labile when are not associated with the RNA chaperone Hfq. This protein is homologous to Sm and Sm-like proteins involved in RNA processing in eukaryotes and it facilitates the sRNA-mRNA pairing. The transient... Read More →
GI

Gulayse Ince Dunn

Rockefeller University | Koc University
Monday September 24, 2012 15:00 - 15:15 @ Rhodes 8    HITS-CLIP reveals nElavl proteins regulate RNA splicing and steady state levels to control brain glutaminase expression and neuronal excitability Abstract: Eukaryotic cells have evolved numerous RNA-based post-transcriptional mechanisms to diversify and regulate gene expression. While little is known about such mechanisms, they are especially widespread in the nervous... Read More →
FH

Felix Halbach

Max-Planck Institute of Biochemistry
Monday September 24, 2012 15:15 - 15:30 @ Rhodes 8    Crystal structure and substrate channeling of the yeast Ski2-3-8 complex Abstract: Degradation of ribonucleic acids (RNA) is an important mechanism that regulates gene expression and enforces transcriptome integrity. The exosome is the major eukaryotic 3' – 5' exonuclease. It is involved in processing and degradation of various types of nuclear RNA. In the cytoplasm... Read More →
avatar for Janosch Hennig

Janosch Hennig

Helmholtz Zentrum München
Monday September 24, 2012 16:15 - 16:30 @ Rhodes 8   Structural basis of the translational regulation of msl2 mRNA by SXL and UNR during dosage compensation in Drosophila Abstract: The protein Upstream of N-Ras (UNR) is a key regulator of gene expression at the translational level in both humans and Drosophila. In Drosophila, UNR and the female-specific protein Sex-lethal (SXL) bind cooperatively to the 3' UTR of msl2 mRNA, which... Read More →
MW

Matthias W. Hentze

EMBL
Monday September 24, 2012 15:45 - 16:15 @ Rhodes 8   Insights into RNA biology from eukaryotic cell mRNA interactomes Abstract: RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV-crosslinking of RBPs to RNA, we have used a systematic, unbiased and comprehensive approach to define the mRNA interactome of proliferating human HeLa cells. Of the proteins captured... Read More →
AR

Alberto R. Kornblihtt

University of Buenos Aires
Monday September 24, 2012 16:30 - 17:00 @ Rhodes 8    Chromatin and transcription regulate alternative splicing Abstract: Regulation of alternative splicing (AS) by transcription elongation can occur via changes in the RNA polymerase II (pol II) molecule itself or in chromatin structure. The first mode is illustrated by the effects of DNA damage caused by UV irradiation on AS. The UV effect is p53-independent, does not imply... Read More →


Monday September 24, 2012 3:00pm - 5:00pm
Rhodes 8

3:00pm

Signalling in cancer
Speakers
SC

Silu Chen-Lindner

German Cancer Research Center (DKZF)
Monday September 24, 2012 16:15 - 16:30 @ Auditorium    Crosstalk between the Keap1-Bach1-Nrf2 system and autophagy represents a dynamic target in pancreatic cancer cells Abstract: The Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor 2 (Nrf2) pathway regulates free reactive oxygen species (ROS) and is important for cellular redox homeostasis. Under non-stressed condition, Nrf2 binds to Keap1, leading to... Read More →
BD

Bingning Dong

Baylor College of Medicine
Monday September 24, 2012 15:30 - 15:45 @ Auditorium    Nuclear receptor CAR overcomes Wnt/beta-catenin induced liver growth arrest and promotes liver tumorigenesis Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer related mortality worldwide. Aberrant activation of Wnt/beta-catenin contributes to 34% of human HCC. However, beta-catenin activation alone is not sufficient to drive tumorigenesis... Read More →
NE

Nancy E. Hynes

Friedrich Miescher Institute
Monday September 24, 2012 15:45 - 16:15 @ Auditorium    Receptor tyrosine kinases in breast cancer: from mechanisms to therapeutic targeting Abstract: Breast cancer is heterogenous, however, there are specific genetic alterations present in certain patient populations.  The ERBB2 amplicon is found in 25% of breast tumors and monoclonal antibodies and tyrosine kinase inhibitors (TKI) are used to treat these patients... Read More →
AR

Angel R. Nebreda

Institute for Research in Biomedicine (IRB)
Monday September 24, 2012 16:30 - 17:00 @ Auditorium    p38 MAPK signaling in tumorigenesis Abstract: The p38α MAP kinase pathway plays key roles in the cellular responses to stress but can also integrate signals that affect many other cellular processes in a cell context-specific and cell type-specific manner. Studies using genetically modified mice have elucidated some in vivo functions for p38α, and provided... Read More →
GT

George Thomas

Metabolic Diseases Institute, University of Cincinnati | IDIBELL
Monday September 24, 2012 15:00 - 15:30  @ Auditorium Targeting mTOR signaling in HCC: A Therapeutic Approach Abstract: The mTORC1 pathway is upregulated in over 80 percent of solid tumors. In earlier studies, we took advantage of Drosophila genetics to identify a number of the key signaling components in this pathway. These included the tumor suppressor complex TSC1/TSC2 and the proto-oncogene Rheb. In parallel, these studies led to... Read More →


Monday September 24, 2012 3:00pm - 5:00pm
Auditorium

5:00pm

Break
Monday September 24, 2012 5:00pm - 6:30pm
TBA

5:00pm

Science in India

Life Science opportunities in India

A discussion for graduate students, postdocs and group leaders interested in research opportunities in India.

 

New research institutions and universities are being set up in all corners of India creating great opportunities to do research albeit amidst a few challenges. With a success rate of over 40%, research grants in India are probably the easiest to get and there are ample opportunities. Learn about the changes as well as practical information on grants and how to apply for jobs. Half the session will be reserved for questions. This meeting is part of the Young Investigator Meetings intended to facilitate the careers of young scientists of any nationality in India. Individuals interested in pursuing postdoctoral or graduate studies in India will also benefit from this session.

 

For more information, visit www.indiabioscience.org


Speakers
avatar for Athulaprabha Murthi

Athulaprabha Murthi

IndiaBioscience
avatar for Vijayalakshmi Ravindranath

Vijayalakshmi Ravindranath

Indian Institute of Science
avatar for Vidita A. Vaidya

Vidita A. Vaidya

Dept. of Biological Sciences, Tata Institute of Fundamental Research


Monday September 24, 2012 5:00pm - 6:30pm
Rhodes 8

5:00pm

Poster Session B

Session B: Monday 24 September 17:00 - 17:45 odd numbers, 17:45 - 18:30 even numbers @  Exhibition Hall 

 

EMBO Subject Areas:

Cell & Tissue Architecture 
Cell Cycle 
Genomic & Computational Biology 
Membranes & Transport
Proteins & Biochemistry 
Structural Biology & Biophysics 
Systems Biology


Poster sessions are held on the Sunday, Monday and Tuesday in the exhibition hall.  Each session is 1.5 hours, the sessions will be split between odd and even poster numbers, so participants have 45 minutes to present their posters.

 

NOTE: Successful abstract submitters were notified on 24 August which poster session has been allocated to them. Due to the quantity of posters, it is not possible to change the allocated day.

Maximum recommended poster dimensions: 882 x 1,274mm (36" x 49.08") Portrait - DIN A0 Oversize Format.

The abstract book will be available online as a downloadable PDF two weeks prior to the conference to allow all registered participants to review abstracts and highlight posters of interest before arrival.  A printed abstract book will ONLY be available for you if you specify when registering that you would like one at a cost of €5.00. Some copies will be available for purchase onsite (subject to availability).

Please be aware that photographic recording of posters and other presentations is not permitted during the meeting.

Participants were invited to submit abstracts in the following research areas: read more

 

EMBO Scientific Publications poster prizes

The EMBO Editors are highlighting exceptional research presented by young researchers in the poster sessions at The EMBO Meeting. Each of the EMBO Scientific Publications (The EMBO JournalEMBO reportsMolecular Systems Biology and EMBO Molecular Medicine) will award a poster prize to their elected top poster exhibited at the conference. They will be looking for high quality and exciting unpublished research presented in a clear and appealing manner.

How to participate: Submit an abstract to The EMBO Meeting. Your poster will be automatically considered if accepted.

Selections: Selections will be made by the editors  and members of the EMBO Young Investigator Programme and EMBO Installation Grantees based on the abstracts and during the poster sessions.

Prize: Voucher (value: €250) to be used towards the registration fee to any EMBO Course, Workshop or Conference of your choice in 2014.

The awards will be announced and presented during the closing ceremony.

 


Monday September 24, 2012 5:00pm - 6:30pm
Exhibition Hall

6:30pm

Science Policy & Publishing - Disseminating research: From bench to website

Disseminating research: From bench to website

This year EMBO Science Policy and EMBO Publications have joint forces to organize a session on scientific publishing and policy.
The aim is to present and discuss the changes taking place in scientific research and publishing, with a focus on the increasing need for data sharing and reproducibility, and their implications for scientists, publishers, research funders, librarians and others.

 


Speakers
avatar for Michele Garfinkel

Michele Garfinkel

EMBO
Saturday, 22 September, 12:15 - 14:15 @ Le Mykonos Restaurant  Monday September 24, 2012 18:30 - 18:35 @ Rhodes 6    Michele Garfinkel is the manager of the Science Policy Programme at the European Molecular Biology Organization. Previously she was a policy analyst at the J. Craig Venter Institute, where she worked on societal issues related to the emerging technologies of genomics, particularly... Read More →
avatar for Thomas Lemberger

Thomas Lemberger

Chief Editor Molecular Systems Biology and Deputy Head of Scientific Publications, EMBO
Saturday September 22, 2012 14:30 - 17:30 @ Gallieni 5  Sunday September 23, 2012 13:15 - 14:15 @ Agora 2  Monday September 24, 2012 18:50 - 19:05 @ Rhodes 6    Integrating 'Source Data' Into Scientific Papers Abstract: The effective and unrestricted exchange of peer-reviewed research data is essential to the advancement of science. This requires making published data available, searchable and re-usable... Read More →
avatar for Bernd Pulverer

Bernd Pulverer

Chief Editor The EMBO Journal and Head of Scientific Publications, EMBO
Saturday September 22, 2012 14:30 - 17:30 @ Gallieni 5  Sunday September 23, 2012 13:15 - 14:15 @ Agora 2  Monday September 24, 2012 18:35 - 18:50 @ Rhodes 6    Transparent Peer Review Abstract: The peer reviewed research paper remains the main conduit for the exchange of research discoveries. With the growth and diversification of global research, publishing in selected journals and citation... Read More →
avatar for Victoria Stodden

Victoria Stodden

Columbia University
Monday September 24, 2012 19:05 - 19:35 @ Rhodes 6    Towards Reproducible Science: Policy and a Path Forward Abstract: The movement toward disseminating reproducible computational research – where the code and data that generated the results are conveniently available – has attracted serious attention from scientists and policy makers. In the life sciences, researchers particularly in... Read More →


Monday September 24, 2012 6:30pm - 7:45pm
Rhodes 6

6:30pm

Scientific careers - how are they shaped by attitudes and stereotypes? - Brian Nosek

Women in Science

Abstract:

Conscious experience provides an immediate, compelling, and incomplete account of mental life.  Much of perception, thinking, and action is shaped by mental activity that occurs outside of conscious awareness or conscious control.  These "implicit" processes have application in many aspects of social life, but the particular focus of this session is their implications for diversity in science.  Implicit attitudes and stereotypes about gender and science can play a role in participation and performance in scientific careers.


Speakers
avatar for Brian Nosek

Brian Nosek

University of Virginia
Monday September 24, 2012 18:30 - 19:45 @ Auditorium 
avatar for Gerlind Wallon

Gerlind Wallon

Deputy Director, EMBO


Monday September 24, 2012 6:30pm - 7:45pm
Auditorium
 
Tuesday, September 25
 

9:00am

Actin-based motility
Speakers
DH

Dorit Hanein

Sanford-Burnham Medical Research Institute
Tuesday September 25, 2012 09:00 - 09:30 @ Rhodes 6   Structural basis of force transmission during directed cell migration Abstract: Cell migration plays a vital role in “normal” processes such as immune surveillance, inflammation and hemostasis, as well as in pathological processes such as cancer and thrombosis. The heterogeneity and dynamic nature of the multi-component complexes responsible for the transmission of... Read More →
KI

Keith Ireton

University of Otago
Tuesday September 25, 2012 09:30 - 09:45 @ Rhodes 6    The human GTPase Cdc42 restrains intercellular spread of the bacterial pathogen Listeria monocytogenes Abstract: The bacterial pathogen Listeria monocytogenes uses an F-actin –dependent motility process to spread from infected human cells to surrounding cells. In polarized cells, efficient spreading of Listeria requires the secreted bacterial protein InlC. InlC... Read More →
GS

Giorgio Scita

Campus IFOM-IEO
Tuesday September 25, 2012 10:30 - 11:00 @ Rhodes 6 Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    RAB5-induced invadosomes formation promotes tumor dissemination Abstract: Cancer invasion is frequently initiated and sustained by cytoskeletal dynamics that propels migratory protrusions, and pericellular proteolytic activity that remodels the extracellular matrix (ECM). How these two processes are... Read More →
TV

Tea Vallenius

University of Helsinki
Tuesday September 25, 2012 10:15 - 10:30 @ Rhodes 6    Alpha-actinin-1 crosslinks Rac1-induced non-contractile dorsal stress fibers promoting cell spreading and migration Abstract: Mesenchymal cell migration is driven by actin polymerization and actin stress fibers, which are considered to contain alpha-actinin crosslinkers and nonmuscle myosin II motors. Although several actin stress fiber subtypes have been identified in... Read More →
MW

Michael Way

London Research Institute
Tuesday September 25, 2012 09:45 - 10:15 @ Rhodes 6    WIP links Nck to N-WASP during Arp2/3 complex dependent actin polymerization Abstract: Activation of Arp2/3 complex dependent actin polymerization by Nck and N-WASP/WASP signalling networks plays an important role during a variety of cellular processes, including endocytosis, phagocytosis and invadopodia formation.  Unfortunately, during its egress vaccinia virus... Read More →


Tuesday September 25, 2012 9:00am - 11:00am
Rhodes 6

9:00am

Growth control & metabolism
Speakers
AA

Azadeh Arabi

Karolinska Institutet
Tuesday September 25, 2012 10:15 - 10:30 @ Auditorium    A proteomics approach to Fbw7 ubiquitin-ligase substrate identification reveals novel targets Abstract: Fbw7 targets several oncoproteins for proteolysis but, the full range of Fbw7 targets is unknown. Although alterations in Fbw7 function are firmly associated with tumours, an understanding of how regulation of various Fbw7 targets is coordinated and how deregulation... Read More →
CV

Chi Van Dang

University of Pennsylvania
Tuesday September 25, 2012 09:00 - 09:30 @ Auditorium    Targeting Myc-mediated Cancer Metabolism Abstract: The MYC oncogene contributes to the development of the vast majority of human cancers and produces a master transcription factor that regulates cell growth, proliferation, and metabolism.  Myc drives biomass accumulation through directly stimulating ribosome biogenesis, as well as activating genes involved in... Read More →
RL

Renaud Le Floc'h

IRCAN
Tuesday September 25, 2012 09:30 - 09:45 @ Auditorium    CD147 subunit of Lactate/H+ symporters MCT1 & MCT4 is critical for energetics and growth of glycolytic tumors Abstract: Tumor cells metabolism is essentially glycolytic with a sustained production of lactic acid that must be exported to allow cell proliferation. The H+-linked Monocarboxylate Transporters (MCTs) catalyze the diffusion of lactate with H+. We hypothetize... Read More →
SM

Sybille Mazurek

Institute for Veterinary Physiology and Biochemistry
Tuesday September 25, 2012 10:30 - 11:00 @ Auditorium    Bi-functional role of the pyruvate kinase isoenzyme M2 within the tumor metabolome: applications in diagnosis and potential in therapy Abstract: Background: Tumor cells express the pyruvate kinase isoenzyme M2 (M2-PK, PKM2). In contrast to the PK isoenzymes of differentiated tissues (M1, L, R), PKM2 may occur in a highly active tetrameric form, which favors the... Read More →
SM

Salvador Moncada

Wolfson Institute for Biomedical Research
Tuesday September 25, 2012 09:45 - 10:15 @ Auditorium    Connecting cell cycle progression to metabolic requirements Abstract: The activity of key metabolic enzymes is regulated by the ubiquitin ligases that control the function of the cyclins; therefore the activity of these ubiquitin ligases explains the coordination of cell-cycle progression with the supply of substrates necessary for cell duplication. Anaphase-promoting... Read More →


Tuesday September 25, 2012 9:00am - 11:00am
Auditorium

9:00am

Nucleic Acids in defence mechanisms
Speakers
BL

Brenda L. Bass

University of Utah
Tuesday September 25, 2012 09:00 - 09:30 @ Rhodes 7    How much cellular double-stranded RNA is there and what does it do? Abstract: Our previous and ongoing studies indicate that C. elegans deficient for one of several different double-stranded RNA (dsRNA) binding proteins (dsRBPs) aberrantly express genes involved in stress and innate immunity. We hypothesize cells have a characteristic dsRNA:dsRBP ratio, and aberrations from... Read More →
JI

Jean-Luc Imler

IBCM, Université de Strasbourg
Tuesday September 25, 2012 09:45 - 10:15 @ Rhodes 7    Sensing viral nucleic acids by the innate immune system in drosophila Abstract: Viral infection is a major threat for all living organisms, which have evolved efficient antiviral defence mechanisms. Innate immunity is the first-line host defence program, which operates in all animals to inhibit growth of microorganisms and increase host survival. Innate immunity is... Read More →
OY

Oh Youn Kim

Postech
Tuesday September 25, 2012 10:15 - 10:30 @ Rhodes 7    IFN-gamma and IL-17 cell response mediate protective immunity against bacterial-induced sepsis on outer membrane vesicle immunization Abstract: Sepsis is a whole body inflammatory state caused by bacterial or fungal infection. Outer membrane vesicles (OMVs), secreted from Gram-negative bacteria, are spherical nano-meter sized proteolipids enriched with outer membrane... Read More →
JV

John van der Oost

Wageningen University
Tuesday September 25, 2012 10:30 - 11:00 @ Rhodes 7    RNA-based adaptive immunity in prokaryotes Abstract: Bacteria and Archaea can acquire resistance against viruses and plasmids via the recently discovered CRISPR defense system. This system allows a response to invading genetic elements by recognizing, processing and integrating short fragments of alien nucleic acid into repetitive CRISPR loci in the host genome. These... Read More →
MS

Matthias Schaefer

German Cancer Research Center (DKFZ)
Tuesday September 25, 2012 09:30 - 09:45 @ Rhodes 7    Aberrant tRNA Fragmentation in Dnmt2 Mutant Drosophila Interferes with siRNA-Mediated Transposon Control Abstract: Dnmt2 represents the most conserved, yet least understood member of the eukaryotic DNA methyltransferase enzyme family. Since it was published that Dnmt2 enzymes modify tRNA rather than DNA, it remained unclear, which biological function Dnmt2-mediated RNA... Read More →


Tuesday September 25, 2012 9:00am - 11:00am
Rhodes 7

9:00am

The animal germline
Speakers
ED

Emilie Demoinet

McGill University
Tuesday September 25, 2012 09:30 - 09:45 @ Rhodes 8    Stress-dependent transgenerational reduction in brood size and offspring fertility involves AMPK in C. elegans Abstract: Environmentally triggered phenotypes that are heritable from one generation to the next have been found to be associated with DNA methylation and chromatin alterations, causing changes in gene expression. For example, epigenetic alterations arising around... Read More →
SK

Saadi Khochbin

Institut Albert Bonniot
Tuesday September 25, 2012 10:30 - 11:00 @ Rhodes 8   Molecular basis of haploid male genome programming Abstract: Post-meiotic male genome compaction could be considered as conceptually related to sporulation in lower eukaryotes or pollen formation in plants, all involving post-meiotic genome compaction mechanisms of completely unclear nature. In mammals, the current knowledge implies a post-meiotic stepwise replacement of histones... Read More →
RL

Ruth Lehmann

Langone Medical Center, Skirball Institute
Tuesday September 25, 2012 09:00 - 09:30 @ Rhodes 8    Protecting the Germline Abstract: Setting germ cells apart from other cells in the body is crucial for maintenance of all sexually reproducing species. In Drosophila, primordial germ cells (PGCs) from under the control of maternally synthesized germ plasm, while somatic cellularization relies on new, zygotic transcription. Like mice and other species, Drosophila PGCs... Read More →
HL

Huaibiao Li

Leibniz Institute for Age Research - Fritz Lipmann Institute
Tuesday September 25, 2012 10:15 - 10:30 @ Rhodes 8    A common regulator of spermatogenesis and oogenesis with centrosomal function Abstract: Spermatogenesis and oogenesis, the processes of development of mature gametes, have common features but are regulated by distinct mechanisms. In mammals, mature sperm develops via post-embryonic proliferation and differentiation of spermatogonial stem cells, while oocytes, which... Read More →
MS

Mitinori Saitou

Kyoto University
Tuesday September 25, 2012 09:45 - 10:15 @ Rhodes 8    Mechanism and reconstitution in vitro of germ cell specification in mice Abstract: The germ cell lineage ensures the creation of new individuals, thereby perpetuating and diversifying the genetic and epigenetic information across the generations.  We have been investigating signaling, global transcription and epigenetic dynamics associated with germ cell specification... Read More →


Tuesday September 25, 2012 9:00am - 11:00am
Rhodes 8

11:00am

Poster Session C

Session C: Tuesday 25 September 11:00 - 11:45 odd numbers, 11:45 - 12:30 even numbers @  Exhibition Hall 

 

EMBO Subject Areas:

Development 
Differentiation & Death 
Molecular Medicine 
Neuroscience 
Plant Biology 
Signal Transduction

 

Poster sessions are held on the Sunday, Monday and Tuesday in the exhibition hall.  Each session is 1.5 hours, the sessions will be split between odd and even poster numbers, so participants have 45 minutes to present their posters.

 

NOTE: Successful abstract submitters were notified on 24 August which poster session has been allocated to them. Due to the quantity of posters, it is not possible to change the allocated day.

Maximum recommended poster dimensions: 882 x 1,274mm (36" x 49.08") Portrait - DIN A0 Oversize Format.

The abstract book will be available online as a downloadable PDF two weeks prior to the conference to allow all registered participants to review abstracts and highlight posters of interest before arrival.  A printed abstract book will ONLY be available for you if you specify when registering that you would like one at a cost of €5.00. Some copies will be available for purchase onsite (subject to availability).

Please be aware that photographic recording of posters and other presentations is not permitted during the meeting.

Participants were invited to submit abstracts in the following research areas: read more

 

EMBO Scientific Publications poster prizes

The EMBO Editors are highlighting exceptional research presented by young researchers in the poster sessions at The EMBO Meeting. Each of the EMBO Scientific Publications (The EMBO JournalEMBO reportsMolecular Systems Biology and EMBO Molecular Medicine) will award a poster prize to their elected top poster exhibited at the conference. They will be looking for high quality and exciting unpublished research presented in a clear and appealing manner.

How to participate: Submit an abstract to The EMBO Meeting. Your poster will be automatically considered if accepted.

Selections: Selections will be made by the editors  and members of the EMBO Young Investigator Programme and EMBO Installation Grantees based on the abstracts and during the poster sessions.

Prize: Voucher (value: €250) to be used towards the registration fee to any EMBO Course, Workshop or Conference of your choice in 2014.

The awards will be announced and presented during the closing ceremony.

 


Tuesday September 25, 2012 11:00am - 12:30pm
Exhibition Hall

12:30pm

Group Leader Lunch

Tuesday September 25, 2012 12:30 - 13:30 Le Mykonos Restaurant 

Maria Leptin invites group leaders attending The EMBO Meeting in Nice, France to join her for drinks and discussion over lunch

Find out more about what EMBO is doing to make Europe a place where top-level life science research thrives.

This is your opportunity to talk to Maria and EMBO programme managers about the latest developments in the life sciences and to discuss how EMBO supports talented researchers, stimulates scientific exchange and advances policies for a world-class European research environment.

Please confirm if you would like to attend the lunch for group leaders and note this event in your schedule for the conference. Confirmation should be sent by e-mail to the.embo.meeting@embo.org by Monday 17 September 2012.


Speakers
avatar for Maria Leptin

Maria Leptin

EMBO Director, EMBO


Tuesday September 25, 2012 12:30pm - 1:30pm
Le Mykonos Restaurant

12:30pm

Meet the Speakers Lunch

Tuesday September 25, 2012 12:30 - 13:30Agora 2 

 

Meet the keynote and plenary speakers. This is an ideal opportunity, especially for students and younger scientists, to meet the speaker faculty and ask questions.


Speakers
CV

Chi Van Dang

University of Pennsylvania
Tuesday September 25, 2012 09:00 - 09:30 @ Auditorium    Targeting Myc-mediated Cancer Metabolism Abstract: The MYC oncogene contributes to the development of the vast majority of human cancers and produces a master transcription factor that regulates cell growth, proliferation, and metabolism.  Myc drives biomass accumulation through directly stimulating ribosome biogenesis, as well as activating genes involved in... Read More →
avatar for Anne Eichmann

Anne Eichmann

Yale School of Medicine | Inserm
Tuesday September 25, 2012 14:30 - 15:00 @ Auditorium    Guidance of vascular patterning Abstract: My laboratory studies vascular and lymphatic development, with particular interests in mechanisms that direct vascular patterning and guidance. In blood vessels, specialized endothelial cells called tip cells localized at the extremities of growing capillary sprouts mediate guided vascular patterning. Tip cells exhibit... Read More →
AR

Alberto R. Kornblihtt

University of Buenos Aires
Monday September 24, 2012 16:30 - 17:00 @ Rhodes 8    Chromatin and transcription regulate alternative splicing Abstract: Regulation of alternative splicing (AS) by transcription elongation can occur via changes in the RNA polymerase II (pol II) molecule itself or in chromatin structure. The first mode is illustrated by the effects of DNA damage caused by UV irradiation on AS. The UV effect is p53-independent, does not imply... Read More →
RL

Ruth Lehmann

Langone Medical Center, Skirball Institute
Tuesday September 25, 2012 09:00 - 09:30 @ Rhodes 8    Protecting the Germline Abstract: Setting germ cells apart from other cells in the body is crucial for maintenance of all sexually reproducing species. In Drosophila, primordial germ cells (PGCs) from under the control of maternally synthesized germ plasm, while somatic cellularization relies on new, zygotic transcription. Like mice and other species, Drosophila PGCs... Read More →


Tuesday September 25, 2012 12:30pm - 1:30pm
Agora 2

12:30pm

Break
Tuesday September 25, 2012 12:30pm - 2:00pm
TBA

12:30pm

Satellite Symposium / European Research Council

Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6 

 

European Research Council: Funding Opportunities for Investigator-Initiated Frontier Research

The European Research Council is dedicated to funding investigator-driven frontier research with scientific excellence being the sole selection criterion. Grants are awarded to both starting and established researchers, irrespective of their origins, who are working or moving to work in Europe. The audience is invited to be informed on the 2013 ERC Calls. ERC grantees will be present to relate their experiences in a 'Questions and Answers' session.


Speakers
MB

Mónica Bettencourt-Dias

The Instituto Gulbenkian de Ciência (IGC)
Monday September 24, 2012 15:00 - 15:30 @ Rhodes 7  Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    BLD10/CEP135 is a microtubule-­‐associated protein that controls the formation of the flagellum central microtubule pair Abstract: Cilia and flagella are structures involved in a variety of developmental processes and human diseases, including ciliopathies and sterility. We investigate how the... Read More →
LF

Laure Fraysse

ERC
Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6 
GS

Giorgio Scita

Campus IFOM-IEO
Tuesday September 25, 2012 10:30 - 11:00 @ Rhodes 6 Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    RAB5-induced invadosomes formation promotes tumor dissemination Abstract: Cancer invasion is frequently initiated and sustained by cytoskeletal dynamics that propels migratory protrusions, and pericellular proteolytic activity that remodels the extracellular matrix (ECM). How these two processes are... Read More →
LS

Luca Scorrano

University of Geneva Medical School
Sunday September 23, 2012 15:15 - 15:45 @ Rhodes 8  Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    Keeping the endoplasmic reticulum and mitochondria together Abstract: Mitochondria and endoplasmic reticulum (ER) are juxtaposed by specific molecular machinery that we are starting to unravel and that include mitofusin 2 (MFN2), a large mitochondrial GTPase that we identified as the first molecular... Read More →


Tuesday September 25, 2012 12:30pm - 2:00pm
Rhodes 6

2:00pm

Oxygen sensing, vasculogenesis and disease
Speakers
avatar for Kari Alitalo

Kari Alitalo

Molecular/Cancer Biology Program & Finnish Institute for Molecular Medicine, Biomedicum Helsinki, University of Helsinki
Tuesday September 25, 2012 15:00 - 15:30 @ Auditorium    Therapeutic Potential of Vascular Endothelial Growth Factors Abstract: y laboratory studies vascular growth factors to facilitate therapeutics development for cardiovascular diseases and cancer. – Because of the importance of the growth of new blood vessels, or angiogenesis, in tumor progression, the first anti-angiogenic agents have been approved for... Read More →
avatar for Peter Carmeliet

Peter Carmeliet

VIB K.U. Leuven
Tuesday September 25, 2012 14:00 - 14:30 @ Auditorium    Controlling angiogenesis via endothelial metabolism Abstract: Angiogenesis, the growth of new blood vessels, plays a crucial role in numerous diseases, including cancer. Anti-angiogenesis therapies have been developed to deprive the tumor of nutrients. Clinically approved anti-angiogenic drugs offered prolonged survival to numerous cancer patients. However... Read More →
avatar for Anne Eichmann

Anne Eichmann

Yale School of Medicine | Inserm
Tuesday September 25, 2012 14:30 - 15:00 @ Auditorium    Guidance of vascular patterning Abstract: My laboratory studies vascular and lymphatic development, with particular interests in mechanisms that direct vascular patterning and guidance. In blood vessels, specialized endothelial cells called tip cells localized at the extremities of growing capillary sprouts mediate guided vascular patterning. Tip cells exhibit... Read More →

Conference chair
avatar for Jacques Pouysségur

Jacques Pouysségur

Institute de Biologie du Développement et Cancer

Tuesday September 25, 2012 2:00pm - 3:30pm
Auditorium

3:30pm

Closing Address
Speakers
avatar for Maria Leptin

Maria Leptin

EMBO Director, EMBO

Conference chair
avatar for Julie Ahringer

Julie Ahringer

Wellcome Trust/Cancer Research UK Gurdon Institute

Tuesday September 25, 2012 3:30pm - 4:00pm
Auditorium