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Tuesday, September 25 • 9:00am - 11:00am
Nucleic Acids in defence mechanisms

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Brenda L. Bass

University of Utah
Tuesday September 25, 2012 09:00 - 09:30 @ Rhodes 7    How much cellular double-stranded RNA is there and what does it do? Abstract: Our previous and ongoing studies indicate that C. elegans deficient for one of several different double-stranded RNA (dsRNA) binding proteins (dsRBPs) aberrantly express genes involved in stress and innate immunity. We hypothesize cells have a characteristic dsRNA:dsRBP ratio, and aberrations from... Read More →

Jean-Luc Imler

IBCM, Université de Strasbourg
Tuesday September 25, 2012 09:45 - 10:15 @ Rhodes 7    Sensing viral nucleic acids by the innate immune system in drosophila Abstract: Viral infection is a major threat for all living organisms, which have evolved efficient antiviral defence mechanisms. Innate immunity is the first-line host defence program, which operates in all animals to inhibit growth of microorganisms and increase host survival. Innate immunity is... Read More →

Oh Youn Kim

Tuesday September 25, 2012 10:15 - 10:30 @ Rhodes 7    IFN-gamma and IL-17 cell response mediate protective immunity against bacterial-induced sepsis on outer membrane vesicle immunization Abstract: Sepsis is a whole body inflammatory state caused by bacterial or fungal infection. Outer membrane vesicles (OMVs), secreted from Gram-negative bacteria, are spherical nano-meter sized proteolipids enriched with outer membrane... Read More →

John van der Oost

Wageningen University
Tuesday September 25, 2012 10:30 - 11:00 @ Rhodes 7    RNA-based adaptive immunity in prokaryotes Abstract: Bacteria and Archaea can acquire resistance against viruses and plasmids via the recently discovered CRISPR defense system. This system allows a response to invading genetic elements by recognizing, processing and integrating short fragments of alien nucleic acid into repetitive CRISPR loci in the host genome. These... Read More →

Matthias Schaefer

German Cancer Research Center (DKFZ)
Tuesday September 25, 2012 09:30 - 09:45 @ Rhodes 7    Aberrant tRNA Fragmentation in Dnmt2 Mutant Drosophila Interferes with siRNA-Mediated Transposon Control Abstract: Dnmt2 represents the most conserved, yet least understood member of the eukaryotic DNA methyltransferase enzyme family. Since it was published that Dnmt2 enzymes modify tRNA rather than DNA, it remained unclear, which biological function Dnmt2-mediated RNA... Read More →

Tuesday September 25, 2012 9:00am - 11:00am
Rhodes 7

Attendees (5)