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Tuesday, September 25 • 9:00am - 11:00am
Actin-based motility

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Dorit Hanein

Sanford-Burnham Medical Research Institute
Tuesday September 25, 2012 09:00 - 09:30 @ Rhodes 6   Structural basis of force transmission during directed cell migration Abstract: Cell migration plays a vital role in “normal” processes such as immune surveillance, inflammation and hemostasis, as well as in pathological processes such as cancer and thrombosis. The heterogeneity and dynamic nature of the multi-component complexes responsible for the transmission of... Read More →

Keith Ireton

University of Otago
Tuesday September 25, 2012 09:30 - 09:45 @ Rhodes 6    The human GTPase Cdc42 restrains intercellular spread of the bacterial pathogen Listeria monocytogenes Abstract: The bacterial pathogen Listeria monocytogenes uses an F-actin –dependent motility process to spread from infected human cells to surrounding cells. In polarized cells, efficient spreading of Listeria requires the secreted bacterial protein InlC. InlC... Read More →

Giorgio Scita

Tuesday September 25, 2012 10:30 - 11:00 @ Rhodes 6 Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    RAB5-induced invadosomes formation promotes tumor dissemination Abstract: Cancer invasion is frequently initiated and sustained by cytoskeletal dynamics that propels migratory protrusions, and pericellular proteolytic activity that remodels the extracellular matrix (ECM). How these two processes are... Read More →

Tea Vallenius

University of Helsinki
Tuesday September 25, 2012 10:15 - 10:30 @ Rhodes 6    Alpha-actinin-1 crosslinks Rac1-induced non-contractile dorsal stress fibers promoting cell spreading and migration Abstract: Mesenchymal cell migration is driven by actin polymerization and actin stress fibers, which are considered to contain alpha-actinin crosslinkers and nonmuscle myosin II motors. Although several actin stress fiber subtypes have been identified in... Read More →

Michael Way

London Research Institute
Tuesday September 25, 2012 09:45 - 10:15 @ Rhodes 6    WIP links Nck to N-WASP during Arp2/3 complex dependent actin polymerization Abstract: Activation of Arp2/3 complex dependent actin polymerization by Nck and N-WASP/WASP signalling networks plays an important role during a variety of cellular processes, including endocytosis, phagocytosis and invadopodia formation.  Unfortunately, during its egress vaccinia virus... Read More →

Tuesday September 25, 2012 9:00am - 11:00am
Rhodes 6

Attendees (12)