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Monday, September 24 • 3:00pm - 5:00pm
Post-transcriptional control of gene expression

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José Andrade

Universidade Nova de Lisboa
Monday September 24, 2012 15:30 - 15:45 @ Rhodes 8   Important factors in small RNA degradation: contrasting roles of PNPase and Hfq in the regulation of small RNAs Abstract: Bacterial small RNAs (sRNAs) are extremely labile when are not associated with the RNA chaperone Hfq. This protein is homologous to Sm and Sm-like proteins involved in RNA processing in eukaryotes and it facilitates the sRNA-mRNA pairing. The transient... Read More →

Gulayse Ince Dunn

Rockefeller University | Koc University
Monday September 24, 2012 15:00 - 15:15 @ Rhodes 8    HITS-CLIP reveals nElavl proteins regulate RNA splicing and steady state levels to control brain glutaminase expression and neuronal excitability Abstract: Eukaryotic cells have evolved numerous RNA-based post-transcriptional mechanisms to diversify and regulate gene expression. While little is known about such mechanisms, they are especially widespread in the nervous... Read More →

Felix Halbach

Max-Planck Institute of Biochemistry
Monday September 24, 2012 15:15 - 15:30 @ Rhodes 8    Crystal structure and substrate channeling of the yeast Ski2-3-8 complex Abstract: Degradation of ribonucleic acids (RNA) is an important mechanism that regulates gene expression and enforces transcriptome integrity. The exosome is the major eukaryotic 3' – 5' exonuclease. It is involved in processing and degradation of various types of nuclear RNA. In the cytoplasm... Read More →
avatar for Janosch Hennig

Janosch Hennig

Helmholtz Zentrum München
Monday September 24, 2012 16:15 - 16:30 @ Rhodes 8   Structural basis of the translational regulation of msl2 mRNA by SXL and UNR during dosage compensation in Drosophila Abstract: The protein Upstream of N-Ras (UNR) is a key regulator of gene expression at the translational level in both humans and Drosophila. In Drosophila, UNR and the female-specific protein Sex-lethal (SXL) bind cooperatively to the 3' UTR of msl2 mRNA, which... Read More →

Matthias W. Hentze

Monday September 24, 2012 15:45 - 16:15 @ Rhodes 8   Insights into RNA biology from eukaryotic cell mRNA interactomes Abstract: RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV-crosslinking of RBPs to RNA, we have used a systematic, unbiased and comprehensive approach to define the mRNA interactome of proliferating human HeLa cells. Of the proteins captured... Read More →

Alberto R. Kornblihtt

University of Buenos Aires
Monday September 24, 2012 16:30 - 17:00 @ Rhodes 8    Chromatin and transcription regulate alternative splicing Abstract: Regulation of alternative splicing (AS) by transcription elongation can occur via changes in the RNA polymerase II (pol II) molecule itself or in chromatin structure. The first mode is illustrated by the effects of DNA damage caused by UV irradiation on AS. The UV effect is p53-independent, does not imply... Read More →

Monday September 24, 2012 3:00pm - 5:00pm
Rhodes 8

Attendees (15)