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Monday, September 24 • 11:15am - 1:15pm
DNA replication & repair

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John Diffley

London Research Institute
Monday September 24, 2012 11:15 - 11:45 @ Rhodes 6    Early Events in Eukaryotic DNA Replication Abstract: The eukaryotic cell cycle coordinates the accurate duplication and segregation of the genome during proliferation. The large genomes of eukaryotic cells are replicated from multiple replication origins during S phase. These origins are not activated synchronously at the beginning of S phase, but instead fire throughout S... Read More →

Eric Fischer

Friedrich Miescher Institute for Biomedical Research
Monday September 24, 2012 12:30 - 12:45 @ Rhodes 6   The molecular basis of CRL4(DDB2/CSA) ubiquitin ligase architecture, targeting to chromatin, and COP9 signalosome mediated activation Abstract: The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 serves in the initial recognition of UV-induced DNA damages such as 6-4... Read More →

Michael Harris

University College London
Monday September 24, 2012 11:45 - 12:00 @ Rhodes 6    Linking DNA replication checkpoint to cell-cycle transcription reveals a distinct class of G1/S genes Abstract: Replication-induced stress leads to a cellular response to prevent DNA damage and maintain genome integrity. An important part of this response is at the transcriptional level where genes involved in DNA damage repair (DDR) and cell cycle (CC) regulated genes are... Read More →

Caroline Kisker

Universität Würzburg
Monday September 24, 2012 12:00 - 12:30 @ Rhodes 6    Towards damage verification in nucleotide excision repair Abstract: DNA damage recognition by the nucleotide excision repair pathway requires the division of labour into a scanning step identifying helical distortions in the DNA and a proofreading step verifying the presence of a lesion. This proofreading step can be accomplished in eukaryotes by the ten subunit containing... Read More →

Primo Schär

University of Basel, Institute of Biochemistry and Genetics
Monday September 24, 2012 12:45 - 13:15 @ Rhodes 6    DNA Repair and the Dynamics of Cytosine Methylation Abstract: The thymine DNA glycosylase (TDG) is a DNA repair enzyme directed against a broad range of damaged bases in DNA, including the oxidation and deamination products of cytosine and 5-methylcytosine (5-meC). Although this implicates a biological function in mutation avoidance, the phenotype of a Tdg knockout mouse... Read More →

Monday September 24, 2012 11:15am - 1:15pm
Rhodes 6

Attendees (14)