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Monday, September 24 • 3:00pm - 5:00pm
Signalling in cancer

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Silu Chen-Lindner

German Cancer Research Center (DKZF)
Monday September 24, 2012 16:15 - 16:30 @ Auditorium    Crosstalk between the Keap1-Bach1-Nrf2 system and autophagy represents a dynamic target in pancreatic cancer cells Abstract: The Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor 2 (Nrf2) pathway regulates free reactive oxygen species (ROS) and is important for cellular redox homeostasis. Under non-stressed condition, Nrf2 binds to Keap1, leading to... Read More →

Bingning Dong

Baylor College of Medicine
Monday September 24, 2012 15:30 - 15:45 @ Auditorium    Nuclear receptor CAR overcomes Wnt/beta-catenin induced liver growth arrest and promotes liver tumorigenesis Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer related mortality worldwide. Aberrant activation of Wnt/beta-catenin contributes to 34% of human HCC. However, beta-catenin activation alone is not sufficient to drive tumorigenesis... Read More →

Nancy E. Hynes

Friedrich Miescher Institute
Monday September 24, 2012 15:45 - 16:15 @ Auditorium    Receptor tyrosine kinases in breast cancer: from mechanisms to therapeutic targeting Abstract: Breast cancer is heterogenous, however, there are specific genetic alterations present in certain patient populations.  The ERBB2 amplicon is found in 25% of breast tumors and monoclonal antibodies and tyrosine kinase inhibitors (TKI) are used to treat these patients... Read More →

Angel R. Nebreda

Institute for Research in Biomedicine (IRB)
Monday September 24, 2012 16:30 - 17:00 @ Auditorium    p38 MAPK signaling in tumorigenesis Abstract: The p38α MAP kinase pathway plays key roles in the cellular responses to stress but can also integrate signals that affect many other cellular processes in a cell context-specific and cell type-specific manner. Studies using genetically modified mice have elucidated some in vivo functions for p38α, and provided... Read More →

George Thomas

Metabolic Diseases Institute, University of Cincinnati | IDIBELL
Monday September 24, 2012 15:00 - 15:30  @ Auditorium Targeting mTOR signaling in HCC: A Therapeutic Approach Abstract: The mTORC1 pathway is upregulated in over 80 percent of solid tumors. In earlier studies, we took advantage of Drosophila genetics to identify a number of the key signaling components in this pathway. These included the tumor suppressor complex TSC1/TSC2 and the proto-oncogene Rheb. In parallel, these studies led to... Read More →

Monday September 24, 2012 3:00pm - 5:00pm

Attendees (13)