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Tuesday, September 25 • 9:00am - 11:00am
Growth control & metabolism

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Azadeh Arabi

Karolinska Institutet
Tuesday September 25, 2012 10:15 - 10:30 @ Auditorium    A proteomics approach to Fbw7 ubiquitin-ligase substrate identification reveals novel targets Abstract: Fbw7 targets several oncoproteins for proteolysis but, the full range of Fbw7 targets is unknown. Although alterations in Fbw7 function are firmly associated with tumours, an understanding of how regulation of various Fbw7 targets is coordinated and how deregulation... Read More →

Chi Van Dang

University of Pennsylvania
Tuesday September 25, 2012 09:00 - 09:30 @ Auditorium    Targeting Myc-mediated Cancer Metabolism Abstract: The MYC oncogene contributes to the development of the vast majority of human cancers and produces a master transcription factor that regulates cell growth, proliferation, and metabolism.  Myc drives biomass accumulation through directly stimulating ribosome biogenesis, as well as activating genes involved in... Read More →

Renaud Le Floc'h

Tuesday September 25, 2012 09:30 - 09:45 @ Auditorium    CD147 subunit of Lactate/H+ symporters MCT1 & MCT4 is critical for energetics and growth of glycolytic tumors Abstract: Tumor cells metabolism is essentially glycolytic with a sustained production of lactic acid that must be exported to allow cell proliferation. The H+-linked Monocarboxylate Transporters (MCTs) catalyze the diffusion of lactate with H+. We hypothetize... Read More →

Sybille Mazurek

Institute for Veterinary Physiology and Biochemistry
Tuesday September 25, 2012 10:30 - 11:00 @ Auditorium    Bi-functional role of the pyruvate kinase isoenzyme M2 within the tumor metabolome: applications in diagnosis and potential in therapy Abstract: Background: Tumor cells express the pyruvate kinase isoenzyme M2 (M2-PK, PKM2). In contrast to the PK isoenzymes of differentiated tissues (M1, L, R), PKM2 may occur in a highly active tetrameric form, which favors the... Read More →

Salvador Moncada

Wolfson Institute for Biomedical Research
Tuesday September 25, 2012 09:45 - 10:15 @ Auditorium    Connecting cell cycle progression to metabolic requirements Abstract: The activity of key metabolic enzymes is regulated by the ubiquitin ligases that control the function of the cyclins; therefore the activity of these ubiquitin ligases explains the coordination of cell-cycle progression with the supply of substrates necessary for cell duplication. Anaphase-promoting... Read More →

Tuesday September 25, 2012 9:00am - 11:00am

Attendees (8)