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Monday, September 24 • 11:15am - 1:15pm
Causes & consequences of aneuploidy

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Angelika Amon

Massachusetts Institute of Technology
Monday September 24, 2012 12:45 - 13:15 @ Auditorium    Aneuploidy causes proteotoxic stress Abstract: Aneuploidy is defined as a chromosome number that is not a multiple of the haploid complement. Although it has been known for a long time that the condition is associated with many human diseases including cancer, how the condition affects organismal and cellular physiology has until recently not been studied. We have... Read More →

Rolf Jessberger

Dresden University of Technology
Monday September 24, 2012 12:00 - 12:30 @ Auditorium    Properties and Functions of Cohesin in Mammalian Meiosis Abstract: The canonical cohesin complex consists of SMC1, SMC3, and a kleisin, which form a tripartite ring. Additional proteins such as SA, WAPL, PDS5B, Sororin or an acetyl transferase (ECO1/2) interact with the complex. Mammalian meiocytes form several different, spatiotemporally distinct cohesin complexes, for... Read More →

Anastasia Kuznetsova

Max Planck Institute of Biochemistry
Monday September 24, 2012 12:30 - 12:45 @ Auditorium    Transient tetraploidy paves the way to aneuploidy and chromosomal instability by enhancing survival after chromosome segregation errors Abstract: Aneuploidy, defined as alterations in both chromosome number and structure, and chromosomal instability (CIN) are hallmarks of solid tumors. Growing evidence suggests that aneuploidy facilitates carcinogenesis in both mice and... Read More →

Erich A. Nigg

Biozentrum, University of Basel
Monday September 24, 2012 11:15 - 11:45 @ Auditorium    Control of accurate chromosome segregation during mitosis: Aurora B regulates kinetochore-microtubule interactions through phosphorylation of the tripartite Ska complex Abstract: The error-free segregation of duplicated chromosomes during cell division is critical for the development and health of all organisms. Central to chromosome segregation is the mitotic spindle... Read More →

Matthias Samwer

Max Planck Institute for Biophysical Chemistry
Monday September 24, 2012 11:45 - 12:00 @ Auditorium   A novel actin-bundling kinesin that is essential for meiotic cell division Abstract: F-actin networks are involved in many important cellular functions. Dozens of accessory proteins modulate these networks and facilitate their adaptation to specific requirements. Many key constituents of cytoplasmic F-actin networks have been identified and studied in detail. However, there is... Read More →

Monday September 24, 2012 11:15am - 1:15pm

Attendees (3)