The EMBO Meeting

Monday September 24, 2012 12:45 - 13:15 @ Auditorium    Aneuploidy causes proteotoxic stress Abstract: Aneuploidy is defined as a chromosome number that is not a multiple of the haploid complement. Although it has been known for a long time that the condition is associated with many human diseases including cancer, how the c... Read More →

Monday September 24, 2012 12:00 - 12:30 @ Auditorium    Properties and Functions of Cohesin in Mammalian Meiosis Abstract: The canonical cohesin complex consists of SMC1, SMC3, and a kleisin, which form a tripartite ring. Additional proteins such as SA, WAPL, PDS5B, Sororin or an acetyl transferase (ECO1/2) interact with the compl... Read More →

Monday September 24, 2012 12:30 - 12:45 @ Auditorium    Transient tetraploidy paves the way to aneuploidy and chromosomal instability by enhancing survival after chromosome segregation errors Abstract: Aneuploidy, defined as alterations in both chromosome number and structure, and chromosomal instability (CIN) are hallmarks of solid tumors. Growing evi... Read More →

Monday September 24, 2012 11:15 - 11:45 @ Auditorium    Control of accurate chromosome segregation during mitosis: Aurora B regulates kinetochore-microtubule interactions through phosphorylation of the tripartite Ska complex Abstract: The error-free segregation of duplicated chromosomes during cell division is critical for the deve... Read More →

Monday September 24, 2012 11:45 - 12:00 @ Auditorium   A novel actin-bundling kinesin that is essential for meiotic cell division Abstract: F-actin networks are involved in many important cellular functions. Dozens of accessory proteins modulate these networks and facilitate their adaptation to specific requirements. Many key... Read More →