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Sunday, September 23 • 2:30pm - 4:30pm
Organelle junctions & lipid transfer

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Scott Emr

Weill Inst. for Cell and Molecular Biology & Dept. of Molecular Biology and Genetics, Cornell University
Sunday September 23, 2012 14:30 - 15:00 @ Rhodes 8    Regulation of phosphoinositide lipid signaling at organelle contact sites Abstract: Membrane contact sites are closely apposed regions between organelles implicated in intracellular signaling, lipid exchange, and calcium transport. Junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) where the peripheral ER underlies the PM as a network of sheets and... Read More →

Elina Ikonen

University of Helsinki
Sunday September 23, 2012 16:00 - 16:30 @ Rhodes 8    Mechanisms of lipoprotein-derived lipid transfer in mammalian cells Abstract: Background: A major mechanism of lipid entry into mammalian cells is via receptor-mediated endocytosis of low-density lipoprotein (LDL)-particles. While LDL-receptors recycle to the plasma membrane for further cargo uptake the LDL-derived lipids are hydrolyzed in the acidic compartments... Read More →

Laurent Pieuchot

Temasek Life Science Laboratory
Sunday September 23, 2012 15:00 - 15:15 @ Rhodes 8    Visualizing the peroxisomal protein import Abstract: Peroxisomes are ubiquitous eukaryotic organelles that have the remarkable ability to import folded and even oligomeric proteins. This distinguishes the import machinery from the well-characterized translocons of ER and mitochondria where proteins cross the membrane in an unfolded form. Despite successful identification... Read More →

Luca Scorrano

University of Geneva Medical School
Sunday September 23, 2012 15:15 - 15:45 @ Rhodes 8  Tuesday September 25, 2012 12:30 - 14:00 @ Rhodes 6    Keeping the endoplasmic reticulum and mitochondria together Abstract: Mitochondria and endoplasmic reticulum (ER) are juxtaposed by specific molecular machinery that we are starting to unravel and that include mitofusin 2 (MFN2), a large mitochondrial GTPase that we identified as the first molecular... Read More →

Alejandro Sodero

Katholieke Universiteit Leuven
Sunday September 23, 2012 15:45 - 16:00 @ Rhodes 8    Regulation of neuronal cholesterol content by glutamate/calcium-mediated CYP46A1 activation Abstract: The deregulation of brain cholesterol metabolism is typical in acute neuronal injury and chronic neurodegenerative diseases, and is paralleled by abnormal levels of the cholesterol metabolite 24S-hydroxycholesterol. Since both conditions are characterized by excessive... Read More →

Sunday September 23, 2012 2:30pm - 4:30pm
Rhodes 8

Attendees (8)