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Saturday, September 22 • 5:45pm - 6:30pm
Controlling the cell cycle - Paul Nurse

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Keynote Lecture


Both S-phase and mitosis are common to all cell cycles and both are necessary for the two newly divided cells to receive a full complement of genes.  In fission yeast the onset of S-phase and mitosis can be controlled by a single cyclin dependent kinase (CDK) with different levels of CDK activity bringing about progression through the cell cycle in an orderly fashion.  A low CDK activity is sufficient to bring about S-phase whilst a high activity blocks a further S-phase and is needed for onset of mitosis.  A G2 cell can be programmed to undergo either S-phase or mitosis simply by modifying CDK activity indicating there is no inherent direction in the cell cycle.  Activation of CDK activity is determined by growth rate and cell size, with cell size determined in part by a gradient mechanism.  A genomic wide screen for small sized mutants has identified new genes that act in previously unidentified pathways to regulate CDK activity at mitotic onset.

avatar for Maria Leptin

Maria Leptin

EMBO Director, EMBO
avatar for Paul Nurse

Paul Nurse

Saturday September 22, 2012 17:45 - 18:30 @ Auditorium 

Saturday September 22, 2012 5:45pm - 6:30pm

Attendees (35)